Sort   by:  
 Page size 
ProteomicsLenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
Krönke J, Udeshi ND, Narla A, Grauman P, Hurst SN, McConkey M, Svinkina T, Heckl D, Comer E, Li X, Ciarlo C, Hartman E, Munshi N, Schenone M, Schreiber SL, Carr SA, Ebert BL. Science 2014, 343, 301-305. doi:10.1126/science.1244851. Lenalidomide is a drug with clinical efficacy in multiple myeloma an...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-01-26 | MSV000079017 | MassIVE
GenomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression [ChIP-seq]
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells. ChIP-seq for 2 histone modifications and total H3 (for quantitative normalization) in biological triplicates of cord blood, adult bone marrow, and UNC0638-treated adult bone marrow.
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-69516 | biostudies-arrayexpress
TranscriptomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression [RNA-seq]
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells. RNA-Seq in primary adult human erythroid cells treated with UNC0638 or the vehicle control (DMSO) in biological triplicates.
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-71421 | biostudies-arrayexpress
OtherLenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
Data from Massive, ID: MSV000079017. Experiment: KGG, Rep2, file: G20121009_NU_Ebert_KGG_L-1uMLen_M-No_H-20uMThal_Rep02_bRPFxn06.mzml. Published as part of Science. 2014 Jan 17;343(6168):301-5 . From the Abstract: {{i}} Lenalidomide is a drug with clinical efficacy in multiple myeloma and other B c...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310006306 | GPMDB
Resource Reanalysis 
Genomicsena-DATASET-IJC-07-11-2014-17:58:39:549-794 - samples
Cancer exome reads consisting of FASTQ paired end reads from bone marrow samples
EGAD00001001058 | EGA
GenomicsMDS Sequencing Project Cancer Cell
Myelodysplastic syndromes (MDS) are uncommon entities, heterogeneous clinically and cytogenetically. The aim of the present study is to determine genetic alteration in this subset of patients. Expected results: Identification of new aberrations and genetic markers in order to detect novel genes invo...
EGAS00001001011 | EGA
GenomicsIJC Myelodysplastic Syndromes Sequencing Group
Data Access Committee EGAC00001000257
EGAC00001000257 | EGA
ProteomicsLenalidomide induces ubiquitination and degradation of casein kinase 1A1 in del(5q) MDS
Not available
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-01-26 | MSV000079014 | MassIVE
UnknownDelineation of a KDM2B-related neurodevelopmental disorder and its associated DNA methylation signature.
Not available
S-EPMC9825659 | biostudies-literature
UnknownHaploinsufficiency of ZFHX3, encoding a key player in neuronal development, causes syndromic intellectual disability.
Not available
S-EPMC10940049 | biostudies-literature
Sort   by:  
 Page size