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TranscriptomicsDisrupting SUMOylation potentiates transactivation function and ameliorates polyglutamine AR-mediated disease
Our findings demonstrate beneficial effects of enhancing transactivation function of the ligand-activated polyQ AR and indicate that the SUMOylation pathway may provide new targets for therapeutic intervention. We mutated conserved lysines in the polyQ AR that are targeted by SUMO, a modification th...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-60691 | biostudies-arrayexpress
TranscriptomicsTranscription factors OVOL1 and OVOL2 induce the mesenchymal to epithelial transition in human cancer
This paper shows, for the first time, a novel function of the OVO-like proteins (OVOL1and OVOL2) as critical inducers of mesenchymal to epithelial transition (MET) in human cancer. Examination of the effects of OVOL1 and OVOL2 overexpression in a prostate cancer model.
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-48230 | biostudies-arrayexpress
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