Disrupting SUMOylation potentiates transactivation function and ameliorates polyglutamine AR-mediated disease

ABSTRACT: Our findings demonstrate beneficial effects of enhancing transactivation function of the ligand-activated polyQ AR and indicate that the SUMOylation pathway may provide new targets for therapeutic intervention. We mutated conserved lysines in the polyQ AR that are targeted by SUMO, a modification that inhibits AR transactivation function.

ORGANISM(S): Mus musculus

SUBMITTER: Richard McEachin 

PROVIDER: E-GEOD-60691 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress