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UnknownValidating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B.

Background

Although alcohol risk is heritable, few genetic risk variants have been identified. Longitudinal electronic health record (EHR) data offer a largely untapped source of phenotypic information for genetic studies, but EHR-derived phenotypes for harmful alcohol exposure have yet to b...
S-EPMC5501250 | biostudies-literature
UnknownBlastulation timing is associated with differential mitochondrial content in euploid embryos.

Purpose

Preimplantation genetic screening (PGS) and assessment of mitochondrial content (MC) are current methods for selection of the best embryos for transfer. Studies suggest that time-lapse morphokinetics (TLM) may also be helpful for selecting embryos more likely to implant. In our study...
S-EPMC5949106 | biostudies-literature
UnknownBiologic dose escalation in inflammatory bowel disease in the United States.

Background

Treatment for inflammatory bowel disease (IBD), composed of Crohn disease (CD) and ulcerative colitis (UC), frequently employs biologics to help control inflammation, reduce symptom burden, and limit disease progression. Because of both the lifelong, progressive nature of disease ...
S-EPMC12948753 | biostudies-literature
UnknownA functional macrophage migration inhibitory factor promoter polymorphism is associated with reduced diffusing capacity.
Cigarette smoke exposure is the leading modifiable risk factor for chronic obstructive pulmonary disease (COPD); however, the clinical and pathologic consequences of chronic cigarette smoke exposure are variable among smokers. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine im...
S-EPMC6397351 | biostudies-literature
UnknownValidation for using electronic health records to identify community acquired pneumonia hospitalization among people with and without HIV.

Background

Cohort studies identifying the incidence, complications and co-morbidities associated with community acquired pneumonia (CAP) are largely based on administrative datasets and rely on International Classification of Diseases (ICD) codes; however, the reliability of ICD codes for ho...
S-EPMC7382068 | biostudies-literature
UnknownCannabis Use and Self-Reported Bothersome Symptoms in People with HIV.

Objective

While cannabis use is common among people with HIV (PWH), there have been few studies examining the association of use with health outcomes among PWH. We aimed to evaluate the association between cannabis use and bothersome physical and mental health symptoms using both self-report...
S-EPMC11831903 | biostudies-literature
UnknownImpact of intensity of behavioral treatment, with or without medication treatment, for opioid use disorder on HIV outcomes in persons with HIV.

Background

Persons with HIV (PWH) and opioid use disorder (OUD) can have poor health outcomes. We assessed whether intensity of behavioral treatment for OUD (BOUD) with and without medication for OUD (MOUD) is associated with improved HIV clinical outcomes.

Methods

We used Veterans Ag...
S-EPMC8628025 | biostudies-literature
UnknownLarge-scale polymeric carbon nanotube membranes with sub-1.27-nm pores.
We report the first characterization study of commercial prototype carbon nanotube (CNT) membranes consisting of sub-1.27-nm-diameter CNTs traversing a large-area nonporous polysulfone film. The membranes show rejection of NaCl and MgSO4 at higher ionic strengths than have previously been...
S-EPMC5844709 | biostudies-literature
UnknownT Lymphocyte Subsets Associated With Prevalent Diabetes in Veterans With and Without Human Immunodeficiency Virus.

Background

A higher proportion of circulating memory CD4+ T cells is associated with prevalent diabetes mellitus in the general population. Given the broad changes in adaptive immunity, including memory T-cell expansion, and rising prevalence of diabetes in the human immunodeficiency virus (...
S-EPMC7323499 | biostudies-literature
UnknownPredictors of initiation of and retention on medications for alcohol use disorder among people living with and without HIV.

Introduction

Infrequent use of and poor retention on evidence-based medications for alcohol use disorder (MAUD) represent a treatment gap, particularly among people living with HIV (PLWH). We examined predictors of MAUD initiation and retention across HIV status.

Methods

From Veterans...
S-EPMC6982467 | biostudies-literature
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