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GenomicsWhole Genome Sequencing of a Triple Negative Breast Cancer Patient: Matched Primary Tumor, Normal, Metastasis and Xenograft samples

Breast Cancer Subject Participant ID 700064 (Source Sample names: 6888 and 206). We used massively parallel DNA sequencing technologies to screen entire genomes, in an unbiased manner, for genetic changes associated with tumor growth and metastasis. We describe the complete genome sequence ...

phs000245.v1.p1 | EGA
UnknownEarly developmental outcome in children with hypoplastic left heart syndrome and related anomalies: the single ventricle reconstruction trial.

Background

Survivors of the Norwood procedure may experience neurodevelopmental impairment. Clinical trials to improve outcomes have focused primarily on methods of vital organ support during cardiopulmonary bypass.

Methods and results

In the Single Ventricle Reconstruction trial of t...
S-EPMC3341507 | biostudies-literature
UnknownTechnical performance score is associated with outcomes after the Norwood procedure.

Objectives

The technical performance score (TPS) has been reported in a single center study to predict the outcomes after congenital cardiac surgery. We sought to determine the association of the TPS with outcomes in patients undergoing the Norwood procedure in the Single Ventricle Reconstru...
S-EPMC4253672 | biostudies-literature
UnknownFactors associated with neurodevelopment for children with single ventricle lesions.

Objective

To measure neurodevelopment at 3 years of age in children with single right-ventricle anomalies and to assess its relationship to Norwood shunt type, neurodevelopment at 14 months of age, and patient and medical factors.

Study design

All subjects in the Single Ventricle Reco...
S-EPMC4356168 | biostudies-literature
UnknownCause, timing, and location of death in the Single Ventricle Reconstruction trial.

Objectives

The Single Ventricle Reconstruction trial randomized 555 subjects with a single right ventricle undergoing the Norwood procedure at 15 North American centers to receive either a modified Blalock-Taussig shunt or right ventricle-to-pulmonary artery shunt. Results demonstrated a rat...
S-EPMC3539407 | biostudies-literature
UnknownImpact of pre-stage II hemodynamics and pulmonary artery anatomy on 12-month outcomes in the Pediatric Heart Network Single Ventricle Reconstruction trial.

Objective

To compare the interstage cardiac catheterization hemodynamic and angiographic findings between shunt types for the Pediatric Heart Network Single Ventricle Reconstruction trial. The trial, which randomized subjects to a modified Blalock-Taussig shunt (MBTS) or right ventricle-to-p...
S-EPMC4053497 | biostudies-literature
UnknownPrenatal diagnosis and risk factors for preoperative death in neonates with single right ventricle and systemic outflow obstruction: screening data from the Pediatric Heart Network Single Ventricle Reconstruction Trial(∗).

Objectives

The purpose of this analysis was to assess preoperative risk factors before the first-stage Norwood procedure in infants with hypoplastic left heart syndrome and related single-ventricle lesions and to evaluate practice patterns in prenatal diagnosis, as well as the role of prenat...
S-EPMC3143839 | biostudies-literature
UnknownVariation in perioperative care across centers for infants undergoing the Norwood procedure.

Objectives

In the Single Ventricle Reconstruction trial, infants undergoing the Norwood procedure were randomly allocated to undergo a right ventricle-to-pulmonary artery shunt or a modified Blalock-Taussig shunt. Apart from shunt type, subjects received the local standard of care. We evalua...
S-EPMC3444656 | biostudies-literature
UnknownIntermediate-term mortality and cardiac transplantation in infants with single-ventricle lesions: risk factors and their interaction with shunt type.

Objective

The study objective was to identify factors associated with death and cardiac transplantation in infants undergoing the Norwood procedure and to determine differences in associations that might favor the modified Blalock-Taussig shunt or a right ventricle-to-pulmonary artery shunt....
S-EPMC3359406 | biostudies-literature
UnknownVariation in feeding practices following the Norwood procedure.

Objectives

To assess variation in feeding practice at hospital discharge after the Norwood procedure, factors associated with tube feeding, and associations among site, feeding mode, and growth before stage II.

Study design

From May 2005 to July 2008, 555 subjects from 15 centers were...
S-EPMC3946861 | biostudies-literature
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