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TranscriptomicsBlood gene expression profile of control and crystalline silica exposed rats
The present research aimed to investigate peripheral blood gene expression profiling as a minimally invasive surrogate approach to study silica-induced pulmonary toxicity. Rats were exposed to crystalline silica by inhalation (15 mg/m3, 6 hours/day, 5 days). Pulmonary damage and blood gene expressio...
ORGANISM(S): Rattus norvegicus 
2011-12-02 | E-GEOD-27023 | biostudies-arrayexpress
TranscriptomicsTranscriptomics Analysis of Lungs and Peripheral Blood of Crystalline Silica Exposed Rats
Non-invasive or minimally invasive surrogate approaches to detect/predict target organ toxicity have significant practical applications in occupational toxicology. Presently, using a rat model, we have investigated the potential application of peripheral blood transcriptomics as a practical approach...
ORGANISM(S): Rattus norvegicus 
2012-12-31 | E-GEOD-36208 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD8 T cells in systemic lupus erythematosus (SLE) and vasculitis
Autoimmune diseases are common and debilitating, but their severe manifestations could be reduced if biomarkers were available to allow individual tailoring of the potentially toxic immunosuppressive therapy required for their control. Clinically useful biomarkers have been identified using DNA micr...
ORGANISM(S): Homo sapiens 
2010-06-02 | E-MTAB-157 | biostudies-arrayexpress
UnknownRationale and Design of the CREDENCE Trial: computed TomogRaphic evaluation of atherosclerotic DEtermiNants of myocardial IsChEmia.
Not available
S-EPMC5053174 | biostudies-literature
UnknownCLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.
Not available
S-EPMC5431906 | biostudies-literature
UnknownG protein-coupled receptor kinase 5 regulates thrombin signaling in platelets via PAR-1.
Not available
S-EPMC9006276 | biostudies-literature
TranscriptomicsMolecular insights into the progression of crystalline silica-induced pulmonary toxicity in rats
Identification of molecular target(s) and mechanism(s) of silica-induced pulmonary toxicity is important for the intervention and/or prevention of diseases associated with occupational exposure to crystalline silica. Rats were exposed to crystalline silica by inhalation (15 mg/m3, 6 h/day, 5 days) a...
ORGANISM(S): Rattus norvegicus 
2012-06-29 | E-GEOD-32147 | biostudies-arrayexpress
TranscriptomicsBiological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols
We compared early biological changes in mice after inhalation exposures to cigarette smoke or e-vapor aerosols (MarkTen® cartridge with Carrier, Test-1, or Test-2 formulations; 4% nicotine). Female C57BL/6 mice were exposed to 3R4F cigarette smoke or e-vapor aerosols by nose-only inhalation for up t...
ORGANISM(S): Mus musculus 
2021-02-28 | E-MTAB-10166 | biostudies-arrayexpress
GenomicsJ.Costello_20191016_dataset_rnaseq - samples
Description not provided
EGAD00001005435 | EGA
GenomicsInhibiton of the GABPB1L-containing GABP tetramer is sufficient to reverse replicative immortality in TERT promoter mutant glioblastoma cells.
Over 50 types of cancer acquire TERT promoter mutations. These single point mutations reactivate telomerase, allowing for indefinite maintenance of telomere length and enabling cellular immortalization. The transcription factor binding site created by the point mutations specifically recruit the ETS...
EGAS00001002582 | EGA
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