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ProteomicsA genetic model for in vivo proximity labeling of the mammalian secretome
Yang R, Meyer AS, Droujinine I, Udeshi ND, Hu Y, Guo J, McMahon J, Carey DK, Xu C, Qiao F, Sha J, Qin S, Rocco D, Wohlschlegel J, Ting AY, Carr SA, Perrimon N, McMahon AP. 2022. Organ functions are highly specialized and interdependent. Tissue-specific secreted factors play a critical role in organ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-02-16 | MSV000088848 | MassIVE
TranscriptomicsGene expression profiling of constitutive activation of Smoothened in the mouse uterus
In order to gain a better understanding of Ihh action during embryo implantation, we constitutively activated Smo in the murine uterus using the PRcre mouse model (PRcre/+SmoM2+; SmoM2). Female SmoM2 mice were infertile. They exhibited normal serum progesterone levels and normal ovulation, but ova ...
ORGANISM(S): Mus musculus 
2010-04-13 | E-GEOD-17263 | biostudies-arrayexpress
TranscriptomicsmRNAseq analysis of Nkx2.2, Nkx6.1, and Olig2 overexpression in neural progenitors
Nkx2.2, Nkx6.1, and Olig2 repressors were overexpressed, singly or in combination, in in vitro-derived mouse neural progenitors to identify thier repression targets Overexpression study to identify genes repressed by Nkx2.2, Nkx6.1, and Olig2 in neural progenitors
ORGANISM(S): Mus musculus 
2015-08-24 | E-GEOD-65457 | biostudies-arrayexpress
GenomicsRegulation of Ptch1 expression in the limb
Ptch1 is a critical negative feedback regulator of the Hedgehog signaling and is upregulated in response to pathway activation. How tissue specific responses are mediated remains unknown. Here, we performed ChIP-seq analysis for epitope-tagged endogenous Gli3 protein to identify limb-specific bindin...
ORGANISM(S): Mus musculus 
2014-07-03 | E-GEOD-52939 | biostudies-arrayexpress
GenomicsChIP-seq analysis of Gli1 and Sox2 input to neural progenitor program and integration with actve histone marks
In the vertebrate neural tube, regional Sonic hedgehog (Shh) signaling invokes a time- and concentration-dependent induction of six different cell populations mediated through Gli transcriptional regulators. Elsewhere in the embryo, Shh/Gli responses invoke different tissue appropriate regulatory pr...
ORGANISM(S): Mus musculus 
2012-12-15 | E-GEOD-42132 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses to Sonic Hedgehog pathway stimulation in in vitro derived neural progenitors
The objective of this study was to identify genes regulated by Sonic Hedgehog pathway stimulation in neural progenitors. Paired (parallel culture) triplicates of neuralized embryoid body cultures with and without Shh pathway stimulation (Ag1.3-treatment)
ORGANISM(S): Mus musculus 
2012-12-15 | E-GEOD-42565 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses to GSK3 inhibitor and MEK inhibitor on 2i-adapted mouse embryonic stem cells
The objective of this study was to investigate the roles of GSK3 inhibitor CHIR99021 and MEK inhibitor PD0325901 on 2i-adapted mouse embryonic stem cells (ESCs) in serum-free conditions.Canonical Wnt signaling supports the pluripotency of mouse ESCs but also promotes differentiation of early mammali...
ORGANISM(S): Mus musculus 
2013-03-01 | E-GEOD-43421 | biostudies-arrayexpress
GenomicsAP-1 family members act at DNA targets in conjunction with Sox9 to promote chondrocyte hypertrophy
A comprehensive analysis of Sox9 binding profiles in developing chondrocytes identified marked enrichment of an AP-1-like motif (Ohba et al. 2015). Here, we have explored the functional interplay between Sox9 and AP-1 in mammalian chondrocyte development. Among AP-1 family members, Jun and Fosl2 wer...
ORGANISM(S): Mus musculus 
2016-02-29 | E-GEOD-73372 | biostudies-arrayexpress
ProteomicsA Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia...
3xFLAG-IPs from HEK293T cell lysates expressing 3xFLAG-bait or 3xFLAG-control. Trypsin Digestion
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-04-09 | MSV000079100 | MassIVE
GenomicsChIP-seq analysis of M-NM-2-catenin in mouse embryonic stem cells treated with GSK3 inhibitor CHIR99021 under serum+LIF standard condition.
The objective of this study was to identify the direct target genes of M-NM-2-catenin acting downstream of canonical Wnt signaling in mouse embryonic stem cells (ESCs).Canonical Wnt signaling supports the pluripotency of mouse ESCs but also promotes differentiation of early mammalian cell lineages. ...
ORGANISM(S): Mus musculus 
2013-03-01 | E-GEOD-43565 | biostudies-arrayexpress
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