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TranscriptomicsChip-chip from pro-B cells with H3K4me3, H3K4me2 and H3K9ac
The transcription factor Pax5 represses B-lineage-inappropriate genes and activates B-cell-specific genes in B-lymphocytes. Here we have identified 170 novel Pax5-activated genes. Conditional mutagenesis demonstrated that the Pax5-regulated genes require continuous Pax5 activity for normal expressio...
ORGANISM(S): Mus musculus 
2007-08-23 | E-GEOD-8472 | biostudies-arrayexpress
TranscriptomicsIGH analysis in pro-B cells with H3K4me3, H3K4me2 and H3K9ac
STAT5 and IL-7 signaling are thought to control B-lymphopoiesis by regulating key transcription factor genes and activating VH gene segments at the Igh locus. Using conditional mutagenesis, we demonstrate that transgenic Bcl2 expression rescued the development of Stat5-deleted pro-B cells by compens...
ORGANISM(S): Mus musculus 
2010-07-28 | E-GEOD-18278 | biostudies-arrayexpress
TranscriptomicsChip-chip from pro-B cells with H3K4me3, H3K4me2 and H3K9ac
The transcription factor Pax5 represses B-lineage-inappropriate genes and activates B-cell-specific genes in B-lymphocytes. Here we have identified 170 novel Pax5-activated genes. Conditional mutagenesis demonstrated that the Pax5-regulated genes require continuous Pax5 activity for normal expressio...
ORGANISM(S): Mus musculus 
2010-05-20 | E-GEOD-15145 | biostudies-arrayexpress
TranscriptomicsThe transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells
Pax5 is a critical regulator of B cell commitment. Here we identified direct Pax5 target genes by streptavidin-mediated ChIP-chip analysis of pro-B cells expressing in vivo biotinylated Pax5. By binding to promoters and enhancers, Pax5 directly regulates the expression of multiple transcription fact...
ORGANISM(S): Mus musculus 
2012-03-29 | E-GEOD-28373 | biostudies-arrayexpress
GenomicsIGH analysis in pro-B cells with H3K4me3, H3K4me2, H3K9ac, H3K27me3, Pax5 and CTCF [ChIP-Seq]
VH-DJH recombination of the immunoglobulin heavy-chain (Igh) locus is temporally and spatially controlled during early B-cell development, and yet no regulatory elements other than the VH gene promoters have been identified throughout the entire 2.5-Mb VH gene cluster. Here we discovered novel regul...
ORGANISM(S): Mus musculus 
2011-02-11 | E-GEOD-27214 | biostudies-arrayexpress
TranscriptomicsIGH analysis in pro-B cells with H3K4me3, H3K4me2, H3K9ac, H3K27me3, Pax5 and CTCF [ChIP-chip]
VH-DJH recombination of the immunoglobulin heavy-chain (Igh) locus is temporally and spatially controlled during early B-cell development, and yet no regulatory elements other than the VH gene promoters have been identified throughout the entire 2.5-Mb VH gene cluster. Here we discovered novel regul...
ORGANISM(S): Mus musculus 
2011-02-11 | E-GEOD-27074 | biostudies-arrayexpress
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