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ProteomicsCUX1 recruits SWI/SNF to promote chromatin accessibility in human hematopoietic cells
Transcription factors(TF) plays a key role in hematopoiesis via promoting cell-type specific gene expression. A subset of TFs, canonically termed “pioneer factors”, possesses the ability to bind to otherwise inaccessible heterochromatin regions, and recruit additional TFs, co-activators, and chromat...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD037838 | Pride
Human Q-exactive Ip-ms Cux1 Swi/snf Chromatin 
ProteomicsGenomic studies controvert the existence of the CUX1 p75 isoform
CUX1, a homeodomain-containing transcription factor, is recurrently deleted or mutated in multiple tumor types. In myeloid neoplasms, CUX1 deletion or mutation carries a poor prognosis. We have previously established that CUX1 functions as a tumor suppressor in hematopoietic cells across multiple or...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027527 | Pride
Q-exactive Human Cux1 Kg-1 cell line 
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