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TranscriptomicsPACAP dependency of genes regulated in ischemia
We investigated the effects of PACAP treatment, and endogenous PACAP deficiency, on infarct volume, neurological function, and the cerebrocortical transcriptional response in a mouse model of stroke, middle cerebral artery occlusion (MCAO). PACAP-38 administered i.v. or i.c.v. one hour after MCAO si...
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-5902 | biostudies-arrayexpress
TranscriptomicsMacaca Fascicularis Differential Gene Expression Following Stroke: Control versus Tat-NR2B9c Treated Cortex at 1 hour and 6 hours following middle cerebral aretry occlusion (MCAO)
Differential gene expression comparison between cortex of placebo and PSD-95 inhibitor (Tat-NR2B9c), treated cynomolgus macaques at 1 and 6 hours after middle cerebral artery occlusion. The purpose of this study was to identify changes in differential gene expression in the cortex of animals receiv...
ORGANISM(S): Macaca fascicularis 
2012-02-08 | E-GEOD-35589 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse forebrain with induced middle cerebral artery occlusion (MCAO) to study permanent focal cerebral ischemia
profiling gene transcription in a mouse model of permanent focal cerebral ischemia that was induced by middle cerebral artery occlusion (MCAO)
ORGANISM(S): Mus musculus 
2009-03-07 | E-TABM-655 | biostudies-arrayexpress
TranscriptomicsmRNA microarray in MCAo rat model with IV-hUMSC
To evaluate the change of gene expression at cerebral infarction by the treatment of IV-human umblical cord derived mesenchymal stem cell. RNA was isolated from the ipsilateral hemisphere to MCAo in rats. At 72 h post-MCAo, the ipsilateral hemisphere subjected to MCAo was used for mRNA microarray. R...
ORGANISM(S): Rattus norvegicus 
2017-03-01 | GSE78731 | GEO
UnknownPrecision Stroke Animal Models: the Permanent MCAO Model Should Be the Primary Model, Not Transient MCAO.
Not available
S-EPMC5772000 | biostudies-literature
TranscriptomicsExpression data from rat (Sprague Dawley) brain subjected to MCAo.
Middle cerebral artery occlusion (MCAo) in rat represent the ischemic stroke in human. Rodents subjected to MCAo and treated with venom phospholipase A2 showed reduction in infarct volume after 24hours of stroke. We studied the global gene expression of the reduction in infarct volume using Affymetr...
ORGANISM(S): Rattus norvegicus 
2009-09-04 | E-GEOD-17929 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of white and grey matter in the distribution on the middle cerebral artery 6 hours after administration of the saline/catalytic antioxidant AEOL 10150 and ischemia/reperfusion of the MCAO to study the effect of AEOL 10150 on gene expression.
A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. White and grey matter in the distribution on the middle cerebral artery 6 hours after administration of the saline/catalytic antioxidant AEOL 10150 and ischemia/reperfusion of the MCAO; pooled mRNA from 6 bra...
ORGANISM(S): Mus musculus 
2007-12-15 | E-GEOD-63 | biostudies-arrayexpress
GenomicsmRNA Seqeuencing of MCAO and trat pons after stroke [bulk RNA-seq]
mRNA Seqeuencing of MCAO and trat pons after stroke [bulk RNA-seq]
PRJNA818274 | ENA
TranscriptomicsMouse ischemic tolerance genomic analysis of the brain and blood.
Ischemic tolerance can be induced by numerous preconditioning stimuli, including various Toll-like receptor (TLR) ligands. We have shown previously that systemic administration of the TLR4 ligand, lipopolysaccharide (LPS) or the TLR9 ligand, unmethylated CpG ODNs prior to transient brain ischemia in...
ORGANISM(S): Mus musculus 
2011-10-04 | E-GEOD-32529 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptomic profiling of ischemic/reperfusion injury in an in vivo wild-type mouse model.
Ischemic stroke triggers severe focal hypoperfusion accompanied with deprivation of oxygen and glucose to the cerebral tissue, together with loss of ATP, depolorization of neurons, elevated extracellular potassium concentration, and subsequently leads to excitotoxicity as well as increased oxidative...
ORGANISM(S): Mus musculus 
2011-01-10 | E-GEOD-23160 | biostudies-arrayexpress
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