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ProteomicsComprehensive characterization of Minichromosome Maintenance Complex (MCM) protein interactions using affinity and proximity purifications coupled to mass spectrometry.
This project is the complete interactome of the Minichromosome Maintenance (MCM) complex by using AP-MS and BioID approaches for all the different MCM proteins. Overall, our analysis identified unique and shared interaction partners and proteins enriched for distinct biological processes including D...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000080198 | MassIVE
ProteomicsComprehensive characterization of Minichromosome Maintenance Complex (MCM) protein interactions using affinity and proximity purifications coupled to mass spectrometry.
This project is the complete interactome of the Minichromosome Maintenance (MCM) complex by using AP-MS and BioID approaches for all the different MCM proteins. Overall, our analysis identified unique and shared interaction partners and proteins enriched for distinct biological processes including D...
ORGANISM(S): Homo sapiens (Human) 
2016-08-09 | PXD004089 | Pride
Ap-ms Bioid Mcm complex 
ProteomicsDestabilization of the MiniChromosome Maintenance (MCM) complex modulates the cellular response to DNA double strand breaks induced by Etoposide.
DNA replication during S phase involves thousands of replication forks that must be coordinated to ensure that every DNA section is only replicated once. The minichromosome maintenance proteins, MCM2 to MCM7, form a heteromeric DNA helicase required for both initiation of DNA replication and elongat...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD009539 | Pride
Dna repair Mcm protein Etoposide Dna damage Homologous recombination 
GenomicsBAHCC1 binds H4K20me1 to facilitate the MCM complex loading for DNA replication
BAHCC1 binds H4K20me1 to facilitate the MCM complex loading for DNA replication
PRJNA879210 | ENA
TranscriptomicsGenome-wide localization of ORC and MCM binding sites and identification of replication origins in S. pombe
DNA replication of eukaryotic chromosomes initiates at a number of discrete loci, called replication origins. Distribution and regulation of origins are important for complete duplication of the genome. Here, we determined locations of Orc1 and Mcm6, components of pre-replicative complex (pre-RC),...
ORGANISM(S): Schizosaccharomyces pombe 
2010-06-11 | E-GEOD-6523 | biostudies-arrayexpress
GenomicsBAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication
BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication
PRJNA1243461 | ENA
ProteomicsBAHCC1 binds H4K20me1 to facilitate the MCM complex loading for DNA replication
Methylation of histone H4 lysine 20 (H4K20), such as H4K20 mono-methylation (H4K20me1), regulates the biological processes of DNA replication, cell cycle progression, and DNA damage repair1-4. Whereas H4K20me1 is knowingly written by SET85,6 (also known as PR-Set7) and erased by PHF87 (also known as...
ORGANISM(S): Homo sapiens (Human) 
2025-06-06 | PXD036436 | Pride
Bioid Gelc Human Nsaf 
GenomicsBAHCC1 binds H4K20me1 to facilitate the MCM complex loading for DNA replication
Methylation of histone H4 lysine 20 (H4K20), such as H4K20 mono-methylation (H4K20me1), regulates the biological processes of DNA replication, cell cycle progression, and DNA damage repair. Whereas H4K20me1 is knowingly written by SET8 (also known as PR-Set7) and erased by PHF8 (also known as KDM7B)...
ORGANISM(S): Drosophila melanogaster Mus musculus Homo sapiens 
2025-06-03 | GSE213114 | GEO
ProteomicsInhibitory effect of miR-183 on MCM family members
MYCN and HDAC2 jointly repress the transcription of tumor suppressive micro RNA miR-183 in neuroblastoma. Enforced miR-183 expression induces neuroblastoma cell death and inhibits anchorage-independent colony formation and subcutaneous xenograft growth in mice. We here aimed to unravel the miR-183 s...
ORGANISM(S): Homo sapiens (Human) 
2016-06-01 | PXD003596 | Pride
Label-free proteomics Cell cycle progression Eukaryotic genome replication Oncogene Genomic integrity 
GenomicsBAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication
Mono-methylation of histone H4 lysine 20 (H4K20me1) is increasingly appreciated to be critical for regulating genomic DNA replication, cell cycle progression and DNA damage repair. How exactly H4K20me1 regulates these biological processes remains murky. Here, we report that an evolutionarily conserv...
ORGANISM(S): Homo sapiens 
2025-06-03 | GSE293272 | GEO
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