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ProteomicsMDC1 interacts with TOPBP1 to maintain chromosomal stability during mitosis
MDC1 is a large, modular phospho-protein scaffold that mediates recruitment of signaling and repair complexes to sites of DNA double-strand breaks (DSBs). MDC1 is anchored to damaged chromatin through interaction of its C-terminal BRCT-repeat domain with phosphorylated H2AX (γH2AX), where it recruit...
ORGANISM(S): Homo sapiens (Human) 
2019-03-25 | PXD011850 | Pride
Mdc1 topbp1 mitosis 
TranscriptomicsNanopore RNA-seq of human osteosarcoma cell line U2OS treated with siRNA against MDC1, PLRG1, or control siRNA with or without pladienolide B
The purpose was to investigate transcript and splicing changes in U2OS cells following siRNA-mediated depletion of MDC1 and PLRG1 or treatment with the splicing inhibitor pladienolide B. Cells were treated with control siRNA as control condition. Nanopore sequencing of cDNA was performed after libra...
ORGANISM(S): Homo sapiens 
2023-01-11 | E-MTAB-12497 | biostudies-arrayexpress
GenomicsStreptococcus equinus strain:MDC1
Streptococcus equinus strain:MDC1 Genome sequencing
PRJNA647691 | ENA
GenomicsMDC1 maintains active elongation complexes of RNA polymerase II
MDC1 maintains active elongation complexes of RNA polymerase II
PRJNA891669 | ENA
OtherMDC1 maintains active elongation complexes of RNA polymerase II
The role of MDC1 in the DNA damage response has been extensively studied, however, its impact on other cellular processes is not well understood. Here, we describe a role for MDC1 in transcription by regulating the activity of the RNAPolymerase II (RNAPII). Depletion of MDC1 caused a genome-wide red...
ORGANISM(S): Homo sapiens 
2022-11-24 | GSE215990 | GEO
TranscriptomicsAltered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP Inhibition
Invasive lobular carcinoma of the breast (ILC) is typically estrogen receptor α (ER)-positive and presents with biomarkers of anti-estrogen sensitive disease. Unfortunately, patients with ILC face particularly poor long-term outcomes with high recurrence risk, suggesting a divergent endocrine respon...
ORGANISM(S): Homo sapiens 
2025-12-17 | GSE312599 | GEO
GenomicsADAD2 regulates heterochromatin in meiotic and post-meiotic male germ cells via translation of MDC1
ADAD2 regulates heterochromatin in meiotic and post-meiotic male germ cells via translation of MDC1
PRJNA787474 | ENA
UnknownMDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis.
Not available
S-EPMC6509287 | biostudies-literature
GenomicsAltered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP Inhibition
Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP Inhibition
PRJNA1374277 | ENA
TranscriptomicsMediator of DNA damage checkpoint 1 (MDC1) is a novel estrogen receptor co-regulator in invasive lobular carcinoma of the breast
We identified MDC1 as a putative novel transcriptional co-regulator of estrogen receptor alpha (ER) in models of invasive lobular carcinoma. In this study, our goal was to define the contribution of MDC1 to regulation of the ER transcriptome in ILC cell lines versus invasive ductal carcinoma cells.
ORGANISM(S): Homo sapiens 
2021-05-13 | GSE171364 | GEO
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