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ProteomicsInhibition of the mTOR pathway and reprogramming of protein synthesis by MDM4 reduce ovarian cancer metastatic properties.
Background: The expression of MDM4, a well-known p53-inhibitor, is positively associated with chemotherapy response and overall survival in epithelial ovarian cancer (EOC). The basis of this association remains elusive. Since the occurrence of metastasis is one of the factors responsible for the hig...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-05-27 | PXD019935 | Pride
Ovarian cancer Mdm4 3d cell culture 
GenomicsMDM4-related bone marrow failure
MDM4-related bone marrow failure
PRJNA1173764 | ENA
GenomicsThe role of MDM4 in tumors
The role of MDM4 in tumors
PRJNA1016372 | ENA
TranscriptomicsTargeting MDM4/MDM2 binding interface for reactivation of p53 in cancer therapy
The aim of this experiment has been to investigate the transcriptional profile of HCT116 cells treated with Peptide-3 (Pep3) compared to untreated (NT), treated with solvent (DMSO) or with a mutated peptide (Pep3M) cells. Peptide-3 is a dodecapeptide able to interact with MDM2 at the levels of the i...
ORGANISM(S): Homo sapiens 
2017-04-18 | E-GEOD-62855 | biostudies-arrayexpress
GenomicsA Defective Splicing Machinery Promotes Senescence through MDM4 Alternative Splicing
A Defective Splicing Machinery Promotes Senescence through MDM4 Alternative Splicing
PRJNA1027876 | ENA
TranscriptomicsMDM4-related bone marrow failure
We report 6 unrelated individuals with variable BMF phenotypes and hypocellular MDS. The median age at presentation was 10 years (4 weeks - 53 years). Unbiased genomic analysis revealed germline heterozygous variants in MDM4, including 4 null (frameshift, nonsense, and splice-site resulting in prema...
ORGANISM(S): Homo sapiens 
2025-10-16 | GSE279650 | GEO
UnknownMDM4 alternative splicing and implication in MDM4 targeted cancer therapies.
Not available
S-EPMC8727814 | biostudies-literature
GenomicsPRMT1-Mdm4-p53 pathway controls epicardial invasion and cell fate transition
PRMT1-Mdm4-p53 pathway controls epicardial invasion and cell fate transition
PRJNA503912 | ENA
TranscriptomicsRegulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery (BeadChip)
Protein Arginine MethylTransferase 5 (PRMT5) is known to mediate epigenetic control on chromatin and to functionally regulate components of the splicing machinery. In this study we show that selective deletion of PRMT5 in different organs leads to cell cycle arrest and apoptosis. At the molecular le...
ORGANISM(S): Mus musculus 
2013-09-13 | E-GEOD-45269 | biostudies-arrayexpress
TranscriptomicsRegulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery (RNA-Seq)
Protein Arginine MethylTransferase 5 (PRMT5) is known to mediate epigenetic control on chromatin and to functionally regulate components of the splicing machinery. In this study we show that selective deletion of PRMT5 in different organs leads to cell cycle arrest and apoptosis. At the molecular le...
ORGANISM(S): Mus musculus 
2013-09-13 | E-GEOD-45284 | biostudies-arrayexpress
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