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ProteomicsProteomics profiling of human CD34+ cells from MDS bone marrow and healthy control cells
Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic disorders characterized by ineffective blood cell production and a high risk of progression to acute myeloid leukemia (AML). CD34+ hematopoietic stem and progenitor cells (HSPCs) play a critical role in the pathophysiology of...
ORGANISM(S): Homo sapiens (Human) 
2025-11-14 | PXD059857 | Pride
Dia proteomics Npm1 Myelodysplastic syndromes Leukemia Mds fbxo11 
GenomicsFBXO11 is a candidate tumor suppressor in the leukemic transformation of myelodysplastic syndrome
FBXO11 is a candidate tumor suppressor in the leukemic transformation of myelodysplastic syndrome
PRJNA658804 | ENA
TranscriptomicsFBXO11 is a candidate tumor suppressor in the leukemic transformation of myelodysplastic syndrome
This experiment is assocaited with a publication defining a tumor supressor role of FBXO11 in the transformation of MDS. We observe decreased expression of FBXO11 is associated with transformation to secondary AML.
ORGANISM(S): Homo sapiens 
2020-08-24 | GSE156708 | GEO
UnknownFBXO11 suppression rewires an NPM1-centered interactome influencing the progression of myelodysplastic syndrome.
Not available
S-EPMC12807477 | biostudies-literature
UnknownFBXO11 is a candidate tumor suppressor in the leukemic transformation of myelodysplastic syndrome.
Not available
S-EPMC7538974 | biostudies-literature
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