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MetabolomicsA Combined Metabolomic and Proteomic Investigation of the Effects of a Failure to Express Dystrophin in the Mouse Heart
Muscle degeneration in the heart of 1-9 month-old mdx mice (a model for Duchenne muscular dystrophy) has been monitored using metabolomic and proteomic approaches. In both data sets, a pronounced aging trend was detected in control and mdx mice, and this trend was separate from the disease process. ...
2017-03-14 | MTBLS256 | MetaboLights
TranscriptomicsTranscription profiling of mouse hindlimb muscle, comparison of wild type and mdx mice, 7 to 112 Day
Determination of gene expression changes in hindlimb muscle (gastrocnemius/soleus) of mdx (dystrophin-deficient) mice at postnatal ages 7, 14, 23, 28, 56, and 112.
ORGANISM(S): Mus musculus 
2007-10-05 | E-GEOD-1025 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse extraocular muscle, comparison of wild type and mdx mice, 14 to 112 Days
Determination of gene expression changes in extraocular muscle of mdx (dystrophin-deficient) mice at postnatal ages 14, 28, 56, and 112 days. 3 independent replicates/age/strain. Data form part of publications: Human Molecular Genetics 12:1813-1821, 2003 and FASEB Journal 17: 893-895, 2003 (on-lin...
ORGANISM(S): Mus musculus 
2007-10-04 | E-GEOD-1008 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 16-week-old mdx mouse muscles to characterize transcriptional changes induced by dystrophin deficiency.
Despite over 3,000 articles published on dystrophin in the last 15 years, the reasons underlying the progression of the human disease, differential muscle involvement, and disparate phenotypes in different species are not understood. The present experiment employed a screen of 12,488 mRNAs in 16-wk-...
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-466 | biostudies-arrayexpress
ProteomicsiTRAQ Protemics of mdx vs. mdx/Actg1-TG mouse skeletal muscle
Duchenne muscular dystrophy (DMD) is an X-linked recessive disease caused by deleterious mutations in the DMD gene, rendering non-functional forms or complete absence of the protein dystrophin. Eccentric contraction-induced force loss is the most robust and reproducible phenotype of dystrophin-defic...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-22 | PXD009680 | Pride
Mdx Itraq Skeletal muscle 
TranscriptomicsTime-course of mdx and wild type mice
Time-course microarray data set of mdx and wild type mice ranging from 1-20 weeks of age Keywords: time-course
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-1574 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse diaphragm, comparison of wild type and mdx mice, 7 to 112 days
Determination of gene expression changes in diaphragm muscle of mdx (dystrophin-deficient) mice at postnatal ages 7, 14, 23, 28, 56, and 112 days. 3 independent replicates/age/strain. Data form part of publication: Human Molecular Genetics 13:257-269, 2004.
ORGANISM(S): Mus musculus 
2007-10-05 | E-GEOD-1026 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse mdx animals expressing high levels of utrophin therapeutic implications for DMD
Duchenne Muscular Dystrophy (DMD) is a fatal muscle wasting disorder caused by dystrophin deficiency. Previous work suggested that increased expression of the dystrophin-related protein utrophin in the mdx mouse model of DMD can prevent dystrophic pathophysiology. Physiological tests showed that t...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7187 | biostudies-arrayexpress
TranscriptomicsCells isolated from diaphragm of mdx mouse: satellite cells vs. PDGFRa+ cells
Transcriptional profiling of mouse skeletal muscle-derived cells comparing satellite cells with PDGFRa+ cells. Satellite cells and PDGFRa+ cells were directly isolated from diaphragm of dystrophic mdx mouse by FACS. Two-condition experiment, satellite cells vs. PDGFRa+ cells. Freshly isolated. One r...
ORGANISM(S): Mus musculus 
2011-12-08 | E-GEOD-25258 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of skeletal muscle from wild type and mdx mice at three time points
In this study, in order to minimize the genetic variability of muscle samples we have used two approaches. First, we have analyzed the gene expression profile from a single skeletal muscle, the medial gastrocnemius (MG), and not from a pool of different muscles which could have different expression ...
ORGANISM(S): Mus musculus 
2009-04-16 | E-MEXP-1623 | biostudies-arrayexpress
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