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TranscriptomicsXenopus M-phase extract treated induced pluripotent stem cells
Transfer of somatic cell nuclei to enucleated eggs or ectopic expression of specific transcription factors are two different reprogramming strategies used to generate pluripotent cells from differentiated cells. However, they are poorly efficient and other unknown factors might be required to increa...
ORGANISM(S): Mus musculus 
2011-11-21 | E-GEOD-31691 | biostudies-arrayexpress
ProteomicsMCM9 is Required for Mammalian DNA Mismatch Repair
DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects innate DNA polymerase infidelities during replication to maintain genomic integrity. Defects in a subset of MMR genes are associated with hereditary non-polyposis colon cancer and some other sporadic cancers, highlighting...
ORGANISM(S): Homo sapiens (Human) 
2015-08-19 | PXD000212 | Pride
Mcm9 human dna replication helicase mmr mismatch repair 
TranscriptomicsReplication timing of control and suv4-20h (KO and inducible mutant) cells
Although histone modifications have been implicated in many DNA-dependent processes, their precise role in DNA replication remains poorly understood. Here, we show that the regulation of histone H4-K20 methylation states, in particular for the trimethylation, is a critical determinant of licensing a...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-69084 | biostudies-arrayexpress
TranscriptomicsReplication timing of control and siRNA PR-set7 cells
Although histone modifications have been implicated in many DNA-dependent processes, their precise role in DNA replication remains poorly understood. Here, we show that the regulation of histone H4-K20 methylation states, in particular for the monomethylation, is a critical determinant of licensing ...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-69083 | biostudies-arrayexpress
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