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ProteomicsCellular stiffness sensing through talin 1 in tissue mechanical homeostasis
Tissue mechanical homeostasis, the concept that cells sense mechanical properties and alter rates of ECM synthesis, assembly and degradation, is of broad interest in biology and medicine, but there is little direct support or insight into mechanisms. Tissue mechanical properties such as elasticity a...
ORGANISM(S): Homo sapiens (Human) 
2024-07-16 | PXD041630 | Pride
Focal adhesions Stiffness-sensing Mechanical homeostasis Extra-cellular matrix Talin 
GenomicsMechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk
Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk
PRJNA558239 | ENA
GenomicsMesothelial plasticity regulates lung mechanical homeostasis in regeneration and fibrosis
Mesothelial plasticity regulates lung mechanical homeostasis in regeneration and fibrosis
PRJNA1366581 | ENA
GenomicsMesothelial plasticity regulates lung mechanical homeostasis in regeneration and fibrosis
Mesothelial plasticity regulates lung mechanical homeostasis in regeneration and fibrosis
PRJNA1465676 | ENA
GenomicsCell loss disrupts mechanical homeostasis to drive retinal pigment epithelium ageing-like phenotype in vitro
Cell loss disrupts mechanical homeostasis to drive retinal pigment epithelium ageing-like phenotype in vitro
PRJNA1265179 | ENA
GenomicsMechanical force coordinates with estrogen to orchestrate alveolar bone homeostasis via PIEZO1
Mechanical force coordinates with estrogen to orchestrate alveolar bone homeostasis via PIEZO1
PRJNA844902 | ENA
UnknownMechanosensitive subcellular rheostasis drives emergent single-cell mechanical homeostasis.
Not available
S-EPMC4996707 | biostudies-literature
ModelsCarpenter 2024 - Mechanical control of growing and homeostatic epithelia
a computational framework to predict the patterns of cell proliferation in growing epithelial tissues, connecting single-cell behaviors and cell-cell interactions to tissue-level growth. Our model incorporates probabilistic rules governing cell growth, division, and elimination, also taking into acc...
2025-04-22 | MODEL2503030002 | BioModels
TranscriptomicsCell loss disrupts mechanical homeostasis to drive retinal pigment epithelium ageing-like phenotype in vitro
Tissue homeostasis emerges from mechanical feedback loops balanced by cell loss and proliferation, a balance that in postmitotic tissues must be maintained without compensatory proliferation. Yet how these tissues preserve mechanical homeostasis and how this challenges function in ageing remains unc...
ORGANISM(S): Homo sapiens 
2025-06-20 | GSE297557 | GEO
ProteomicsHuman trabecular meshwork LC-MS/MS
The trabecular meshwork (TM) responsible for IOP homeostasis in the eye could sense the IOP fluctuations dynamically and adapt to the mechanical changes appropriately. Cationic mechanosensitive channels (CMCs) have been reported with critical roles in mediating the TM responding to many mechanical f...
ORGANISM(S): Homo Sapiens 
2022-03-14 | PXD032288 |
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