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ProteomicsTalin force coupling underlies eukaryotic cell-substrate adhesion
Integrin-mediated cell adhesion and mechanotransduction are considered key innovations in animal evolution, enabling a specific and physically robust attachment of cells to the extracellular environment. Here, we show that this type of cell adhesion is a specification of an evolutionary conserved fo...
ORGANISM(S): Homo sapiens (Human) Dictyostelium discoideum (Slime mold) 
2025-11-21 | PXD062078 | Pride
Mechanotransduction Mass spectrometry Evolution Talin Adhesion Dictyostelium Integrin 
ProteomicsTensin3 interaction with talin drives formation of fibronectin-associated fibrillar adhesions
The formation of healthy tissue involves continuous remodelling of the extracellular matrix (ECM). Whilst it is known that this requires integrin-associated cell-ECM adhesion sites (CMAs) and actomyosin-mediated forces, the underlying mechanisms remain unclear. Here we examine how tensin3 contribut...
ORGANISM(S): Homo sapiens (Human) 
2022-09-09 | PXD026343 | Pride
Vinculin Fibronectin Tensin Talin Extracellular matrix 
TranscriptomicsHistone Methyltransferase Ezh2 Controls Cell Adhesion and Migration through Direct Methylation of the Extra-Nuclear Protein-Talin
Previously, we suggested a cytosolic role for the histone-methyltransferase Ezh2 in regulating lymphocyte activation, but molecular mechanisms underpinning this extra-nuclear function remained unclear. Here we show that Ezh2 regulates integrin-signaling and adhesion dynamics of neutrophils and dendr...
ORGANISM(S): Mus musculus 
2015-03-09 | E-GEOD-60146 | biostudies-arrayexpress
TranscriptomicsInteraction network of Talin-1 in promoting hepatocellular carcinoma progression
Talin-1, a macromolecular cytoskeletal protein, promotes hepatocellular carcinoma (HCC) progression. However the underlying mechanism of Talin-1 in HCC remains unclear. Analysis of the gene expression profiles of normal control HCC cell (MHCC-97L) and knockdown Talin-1 HCC cells (sh-Talin-1 MHCC-97L...
ORGANISM(S): Homo sapiens 
2016-12-31 | GSE86062 | GEO
ProteomicsCellular stiffness sensing through talin 1 in tissue mechanical homeostasis
Tissue mechanical homeostasis, the concept that cells sense mechanical properties and alter rates of ECM synthesis, assembly and degradation, is of broad interest in biology and medicine, but there is little direct support or insight into mechanisms. Tissue mechanical properties such as elasticity a...
ORGANISM(S): Homo sapiens (Human) 
2024-07-16 | PXD041630 | Pride
Focal adhesions Stiffness-sensing Mechanical homeostasis Extra-cellular matrix Talin 
ProteomicsRole of the Ste20-like kinase SLK in Podocyte Adhesion
SLK controls the cytoskeleton, cell adhesion and migration. Analysis of a protein kinase phosphorylation site dataset showed that podocyte adhesion proteins – paxillin, vinculin and talin-1 may be potential SLK substrates. The project examines if these adhesion proteins are substrates of SLK.
ORGANISM(S): Cercopithecus aethiops (Green monkey) (Grivet) 
2024-01-22 | PXD046962 | Pride
Vinculin Focal adhesion kinase Glomerulonephritis Talin-1 Paxillin 
GenomicsHomo sapiens
Interaction network of Talin-1 in promoting hepatocellular carcinoma progression
PRJNA340158 | ENA
GenomicsNuclear Talin-1 Provides a Bridge Between Cell Adhesion and Gene Expression
Nuclear Talin-1 Provides a Bridge Between Cell Adhesion and Gene Expression
PRJNA814198 | ENA
UnknownMechanical activation of vinculin binding to talin locks talin in an unfolded conformation.
Not available
S-EPMC3980218 | biostudies-literature
UnknownThe mechanical response of talin.
Not available
S-EPMC4941051 | biostudies-literature
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