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TranscriptomicsTranscription profiling by array of rat macrophages from WKY/NCrl and LEW/Crl strains to determine susceptibility to glomerulonephritis
The Wistar-Kyoto (WKY) rat shows marked susceptibility to crescentic glomerulonephritis, while Lewis rats are resistant. Glomerular injury and crescent formation are macrophage-dependent. The aim of this study is to use gene expression profiling to identify genetic factors that determine macrophage ...
ORGANISM(S): Rattus norvegicus 
2011-03-17 | E-MEXP-2624 | biostudies-arrayexpress
TranscriptomicsExpression data from kidneys of rats with and without glomerulonephritis
We investigated a glomerulonephritis (GN) model in rats induced by nephrotoxic serum (NTS) which contains antibodies against the glomerular basement membrane (GBM). The anti-GBM GN model in rats is widely used since its biochemical and histopathological characteristics are similar to crescentic neph...
ORGANISM(S): Rattus norvegicus 
2015-07-06 | E-GEOD-64265 | biostudies-arrayexpress
TranscriptomicsAngiotensin converting enzyme inhibition attenuates insterstitial injury in a murine model of chronic glomerulonephritis
Evolution of glomerulonephritis (GN) to tubulointerstitial disease is a universal antecedent to the development of chronic kidney disease (CKD). There is also evidence that angiotensin converting enzyme (ACE) inhibition may attenuate the development of CKD in some forms of glomerulonephritis. We t...
ORGANISM(S): Mus musculus 
2013-07-30 | E-GEOD-49323 | biostudies-arrayexpress
TranscriptomicsGlomerulonephritis in BXSB/MpJ-Yaa mice
Analysis of glomeruli isolated from kidneys of 4 month male BXSB/MpJ-Yaa. The BXSB/MpJ-Yaa mouse strain is a lupus-prone model. Results provide insight into the pathogenic mechanisms linked to glomerulonephritis in BXSB/MpJ-Yaa mice. The glomeruli were isolated from 6 BXSB/MpJ-Yaa (glomerulonephrit...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-51230 | biostudies-arrayexpress
GenomicsSingle-cell TCR-sequencing of T cells in crescentic glomerulonephritis
Single-cell TCR-sequencing of T cells in crescentic glomerulonephritis
PRJNA924838 | ENA
TranscriptomicsCC chemokine ligand 18 (CCL18) is associated with disease activity and relapse in ANCA-associated crescentic glomerulonephritis
Anti neutrophil cytoplasmic antibody (ANCA) associated vasculitis is the most frequent cause of crescentic glomerulonephritis. Histopathologic features and clinical course of the disease are diverse and judgment of disease activity is often limited due to the lack of reliable activity markers. In or...
ORGANISM(S): Homo sapiens 
2015-09-03 | E-MTAB-1944 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression in the glomerulus of C57BL/6 mice and B6.MRLc1 glomerulonephritis mice
In isolated glomeruli by beads-perfusion methods, microRNA (miRNA) expression was analyzed in healthy C57BL/6 and B6.MRLc1 glomerulonephritis mice. The expression of 1,135 miRNAs was examined, and up-regulated or down-regulated miRNA was determined. These results provide a basical information of mol...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-51209 | biostudies-arrayexpress
ProteomicsReversible SAHH inhibitor protects against glomerulonephritis in lupus-prone NZB/NZW F1 mice by modulating α-actinin-4 associated skeleton organization of podocytes
Glomerulonephritis is one of the major complications and causes of death in systemic lupus erythematosus (SLE). Podocytes can be injured in many forms of glomerular disease, characteristic changes are actin cytoskeleton reorganization of involved foot process. ACTN4, encodes α-actinin-4, an actin-bi...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD010059 | Pride
Α-actinin-4 Integrin-linked kinase Podocyte injury Glomerulonephritis Sahh inhibitor Skeleton organization 
TranscriptomicsAltered modulation of WNT-β-catenin and PI3K/Akt pathways in IgA nephropathy
To uncover new molecular mechanisms involved in IgAN pathogenesis, we compared the genomic profiles of 12 IgAN patients with 8 healthy subjects, We included addiotional disease controls 3 FSGS(Focal Segmenal glomerulosclerosis) patients and 3 membrano proliferative glomerulonephritis type I (MPGN-I)...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-14795 | biostudies-arrayexpress
GenomicsAnnexin A1 exerts renoprotective effects in experimental crescentic glomerulonephritis
Annexin A1 exerts renoprotective effects in experimental crescentic glomerulonephritis
PRJNA842654 | ENA
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