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TranscriptomicsDifferential microRNA profile in frontal cortex of suicide completers compared to control
Background: TrkB-T1 is a BDNF receptor lacking a tyrosine kinase domain that is highly expressed in astrocytes and regulates BDNF-evoked calcium transients. Previous studies indicate that downregulation of TrkB-T1 in frontal cortex may be involved in neurobiological processes underlying suicide. Me...
ORGANISM(S): Homo sapiens 
2012-06-01 | E-GEOD-34120 | biostudies-arrayexpress
TranscriptomicsMethylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia.
Background: Schizophrenia is a severe neuropsychiatric disorder that is hypothesized to result from disturbances in early brain development, and there is mounting evidence to support a role for developmentally-regulated epigenetic variation in the molecular etiology of the disorder. Here, we describ...
ORGANISM(S): Homo sapiens 
2014-09-13 | E-GEOD-61380 | biostudies-arrayexpress
TranscriptomicsMethylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia.
Background: Schizophrenia is a severe neuropsychiatric disorder that is hypothesized to result from disturbances in early brain development, and there is mounting evidence to support a role for developmentally-regulated epigenetic variation in the molecular etiology of the disorder. Here, we describ...
ORGANISM(S): Homo sapiens 
2014-09-18 | E-GEOD-61431 | biostudies-arrayexpress
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