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In humans, mutations in the transcription factor encoding gene, FOXP2, are associated with language and Autism Spectrum (ASD) Disorders, the latter characterized by deficits in social interactions. However, little is known regarding the function of Foxp2 in male or female social behavior. Our previo...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-07 | PXD026978 | Pride
Genomics
NG2 Glia in the Medial Amygdala (MeA) Region of Mice
The molecular phenotype of kisspeptin neurons in the medial amygdala of female mice
Little is known about how Kiss1 cells in the medial amygdala (MeA) are regulated and what other gene transcripts are produced by MeA Kiss1 neurons. Estradiol upregulates Kiss1 expression in the medial amygdala (MeA), but it remains unknown if estradiol regulates other gene transcripts in MeA Kiss1 c...
ORGANISM(S): Mus musculus 
2023-02-13 | GSE224788 | GEO
bulk RNAseq from the medial amygdala of male and female mice
Adolescent Social Isolation Reprograms the Medial Amygdala: Transcriptome and Sex Differences in Reward
Investigating the molecular basis and correlates of anxiety-related and depression-like behaviors, we generated a mouse model consisting of high (HAB) and low (LAB) anxiety-related behavior mice. We utilized the elevated plus-maze for testing the genetic predisposition to anxiety-related behavior an...
ORGANISM(S): Mus musculus 
NRG1-ErbB4 signaling in the medial amygdala regulates sexual motivation in adult male mice
Adolescence is a sensitive window for reward- and stress-associated behavior. Although stress during this period causes long-term changes in behavior in males, how females respond is relatively unknown. Here we show that social isolation stress in adolescence, but not adulthood, induces persistent b...
ORGANISM(S): Mus musculus 
2020-11-30 | GSE146472 | GEO
The “play transcriptome” is sex-specific in the juvenile rat medial amygdala: a role for inhibitory neurons
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