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TranscriptomicsGene expression in striatums of Foxp2-hum, Foxp2-ko and wild-type mice
It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have been positively selected during human evolution due to effects on aspects of speech and language. Here, we introduce these substitutions into the endogenous Foxp2 gene.of mice. Although these mice are gener...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-13588 | biostudies-arrayexpress
TranscriptomicsHumanized Foxp2 Accelerates Making Transitions From Declarative to Procedural Learning
Purpose: Foxp2 is the first and for now the only gene connected to speech and language in humans. Two aminoacid substitutions took place in this protein during recent human evolution, after our split from the last common ancestor with chimpanzees, and are most likely to have undergone positive selec...
ORGANISM(S): Mus musculus 
2014-09-24 | E-GEOD-60659 | biostudies-arrayexpress
ProteomicsSex-specific social behavior and amygdala proteomic deficits in Foxp2+/- mutant mice
In humans, mutations in the transcription factor encoding gene, FOXP2, are associated with language and Autism Spectrum (ASD) Disorders, the latter characterized by deficits in social interactions. However, little is known regarding the function of Foxp2 in male or female social behavior. Our previo...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-07 | PXD026978 | Pride
Aggression Proteomics Sex-specific differences Medial amygdala (mea) Social behavior Foxp2 
GenomicsFoxp2 Overexpression in BACHD mice
Foxp2 Overexpression in BACHD mice
PRJNA414379 | ENA
TranscriptomicsExpression profile of NIH3T3 cells overexpressing FOXP2 or a FOXP2 arrangement (FOXP2-CPED1)
To study the underlying mechanism of tumor initation driven by FOXP2, we performed transcriptome analysis of transformed NIH3T3 overexpressing FOXP2 or FOXP2-CEPD1 and control cells to explore the FOXP2-related transcriptome in tumorigenesis.
ORGANISM(S): Mus musculus 
2019-05-08 | GSE114350 | GEO
GenomicsFOXP2 regulates differential transcriptional programs in human subplate
FOXP2 regulates differential transcriptional programs in human subplate
PRJNA436813 | ENA
Genomicsβ-catenin regulates FOXP2 transcriptional activity via multiple binding sites
β-catenin regulates FOXP2 transcriptional activity via multiple binding sites
PRJNA577855 | ENA
GenomicsAltered social behavior in mice carrying a cortical Foxp2 deletion
Altered social behavior in mice carrying a cortical Foxp2 deletion
PRJNA431442 | ENA
GenomicsHuman-specific transcriptional regulation of CNS development genes by FOXP2
Human-specific transcriptional regulation of CNS development genes by FOXP2
PRJNA119431 | ENA
TranscriptomicsGene expression in striatums of Foxp2-hum, Foxp2-ko and wild-type mice
It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have been positively selected during human evolution due to effects on aspects of speech and language. Here, we introduce these substitutions into the endogenous Foxp2 gene.of mice. Although these mice are gener...
ORGANISM(S): Mus musculus 
2009-03-02 | GSE13588 | GEO
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