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MetabolomicsX chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction

Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. Here we find that impaired glucose homeostasis and muscle weakness in statin-treated f...

2024-05-23 | MTBLS9677 | MetaboLights
TranscriptomicsNon-targeted effects of low dose ionizing radiation act via TGF-beta to promote mammary carcinogenesis
This is a genome-wide approach to identifying genes persistently induced in the mouse mammary gland by acute whole body low dose ionizing radiation (10cGy), 1 and 4 weeks after exposure. Gene expression that is modified under these parameters were compared between Tgfb1 wild type and heterozygote li...
ORGANISM(S): Mus musculus 
2010-03-07 | E-GEOD-18216 | biostudies-arrayexpress
TranscriptomicsDistribution of elongating RNA polymerase II along the 5'/3' regions in xrn1 mutants
Determination of the 3' or 5' intragenic nascent transcriptional rate. Maintaining the proper mRNA levels is a key aspect in the regulation of gene expression. The balance between mRNA synthesis and decay determines these levels. Using a whole-genome analysis, we demonstrate that most yeast mRNAs a...
ORGANISM(S): Saccharomyces cerevisiae 
2013-05-22 | E-GEOD-43602 | biostudies-arrayexpress
UnknownWireless stimulation of antennal muscles in freely flying hawkmoths leads to flight path changes.
Not available
S-EPMC3530516 | biostudies-literature
TranscriptomicsTranscriptomic analysis of the developing cerebellum in a mouse model for SRD5A3-CDG
We generated Srd5a3 cKO mouse in the cerebellum. To analyze the impact of the genetic defect in the mouse transcriptome, we extracted the RNA from the P7 cerebellum in 4 control and 4 mutant mice, from three different litters.
ORGANISM(S): Mus musculus 
2018-06-24 | E-MTAB-6861 | biostudies-arrayexpress
GenomicsCustom 192-plex
VeraCode GoldenGate GT Assay technology
EGAD00010000853 | EGA
TranscriptomicsIntegrated SV40 T/t-antigen Cancer Signature in Aggressive Breast, Prostate and Lung Carcinomas with Poor Prognosis
Understanding the genetic architecture of cancer pathways that distinguishes subsets of human cancer is critical to developing new therapies that better target tumors based upon their molecular expression profiles. In this study, we identify an integrated gene signature from multiple transgenic mo...
ORGANISM(S): Mus musculus 
2007-09-01 | E-GEOD-8666 | biostudies-arrayexpress
TranscriptomicsIntegrated SV40 T/t-antigen Cancer Signature in Aggressive Breast, Prostate and Lung Carcinomas with Poor Prognosis 2
Understanding the genetic architecture of cancer pathways that distinguishes subsets of human cancer is critical to developing new therapies that better target tumors based upon their molecular expression profiles. In this study, we identify an integrated gene signature from multiple transgenic mo...
ORGANISM(S): Mus musculus 
2007-09-01 | E-GEOD-8663 | biostudies-arrayexpress
TranscriptomicsIntegrated SV40 T/t-antigen Cancer Signature in Aggressive Breast, Prostate and Lung Carcinomas with Poor Prognosis 1
Understanding the genetic architecture of cancer pathways that distinguishes subsets of human cancer is critical to developing new therapies that better target tumors based upon their molecular expression profiles. In this study, we identify an integrated gene signature from multiple transgenic mo...
ORGANISM(S): Mus musculus 
2007-09-01 | E-GEOD-8662 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse mammary tumor-initiating cells
Using a syngeneic p53 null mouse mammary gland tumor model that closely mimics human breast cancer, we have identified by limiting dilution transplantation as well as in vitro mammosphere and clonogenic assays a Lin-CD29HighCD24High subpopulation of tumor-initiating cells. Differentially expressed ...
ORGANISM(S): Mus musculus 
2008-10-18 | E-GEOD-8863 | biostudies-arrayexpress
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