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Genomicsmeg-3 meg-4 upregulate endogenous sRNAs targeting RNAi genes and downregulate their mRNAs
meg-3 meg-4 upregulate endogenous sRNAs targeting RNAi genes and downregulate their mRNAs
PRJNA555888 | ENA
Genomicsmeg-3 meg-4 mutants are defective in exogenous RNAi signal amplification
meg-3 meg-4 mutants are defective in exogenous RNAi signal amplification
PRJNA555887 | ENA
ProteomicsProtein-protein interactions of MEG-3 in C. elegans early embryos
We combined in vivo expressed GFP-tagged MEG-3 (GEI-12) with label-free quantitative proteomics to identify protein-protein interactions of MEG-3 in early C. elegans embryos.
ORGANISM(S): Caenorhabditis elegans 
2021-07-01 | PXD012852 | Pride
Ap-ms Early embryo Ppi Meg-3 C. elegans Gei-12 
GenomicsThe hrde-1 mutation suppresses the rde-11 and sid-1 sRNA upregulation phenotype of meg-3 meg-4 mutants
The hrde-1 mutation suppresses the rde-11 and sid-1 sRNA upregulation phenotype of meg-3 meg-4 mutants
PRJNA555889 | ENA
Genomicsmeg-3 meg-4 upregulate endogenous sRNAs targeting RNAi genes and downregulate their mRNAs
sRNAseq was conducted on four independently generated meg-3 meg-4 lines, and upregulation of sRNAs targeting several RNAi genes was found. mRNAseq found that the transcript levels for several of these genes was also down. meg-3 meg-4 mutants also showed a similar pattern of sRNA misregulation as the...
ORGANISM(S): Caenorhabditis elegans 
2019-07-23 | GSE134628 | GEO
Genomicsmeg-3 meg-4 mutants are defective in exogenous RNAi signal amplification
Worms were fed a dsRNA trigger against the pos-1 gene and subjected to sRNAseq to see if they could amplify the exogenous RNAi trigger. meg-3 meg-4 were not able to amplify the signal as robustly as wild-type.
ORGANISM(S): Caenorhabditis elegans 
2019-07-23 | GSE134627 | GEO
GenomicsThe hrde-1 mutation suppresses the rde-11 and sid-1 sRNA upregulation phenotype of meg-3 meg-4 mutants
sRNAseq was conducted on the hrde-1; meg-3 meg-4 triple mutant, revealing that the hrde-1 mutation suppresses the rde-11 and sid-1 sRNA upregulation phenotype of meg-3 meg-4 mutants .    
ORGANISM(S): Caenorhabditis elegans 
2019-07-23 | GSE134629 | GEO
UnknownSingle-molecule dynamics of the P granule scaffold MEG-3 in the Caenorhabditis elegans zygote.
Not available
S-EPMC6589573 | biostudies-literature
UnknownSpatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3.
Not available
S-EPMC5262379 | biostudies-literature
UnknownSp1/3 and NF-1 mediate basal transcription of the human P2X1 gene in megakaryoblastic MEG-01 cells.
Not available
S-EPMC1464135 | biostudies-literature
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