Megakaryocyte - OmicsDI

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Tissue

Megakaryocyte (7)
Blood cell (6)
Blood platelet (6)
Platelet (6)
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Blood (4)
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Hematopoietic multipotent progenitor cell (2)
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Common myeloid progenitor (1)
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Granulocyte monocyte progenitor cell (1)
Leukocyte (1)
Megakaryocyte cell line (1)
Megakaryocyte differentiation (1)
Megakaryocyte progenitor cell (1)
Megakaryocyte-erythroid progenitor cell (1)
Primary cell (1)
Stem cell (1)

Disease

Normal (2)
Not Available (2)
Thrombocytopenia (2)
Unilateral congenital transverse defect of his right upper (absence of forearm and hand) and right lower (absence of foot) limbs; a high platelet count (1)
Erythroleukemia (1)
Megakaryoblastic leukaemia (1)
Megakaryoblastic leukemia (1)
Chronic myeloid leukemia (1)
Disease free (1)
Myeloproliferative neoplasm (1)
Polycythemia vera (1)
Sitosterolemia (1)
Thrombocytopenia (1)

Technology Type

Fluorescence intensity (26)
MEMA (26)
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Mass spectrometry (5)
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Mass spectrometry assay (4)
ILLUMINA, Illumina HiSeq 2000 (3)
Affinity purification coupled with mass spectrometry proteomics (2)
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DiaPASEF (2)
Applied Biosystems (1)
Illumina HiSeq 4000, ILLUMINA (1)
Illumina HiSeq 2500 (1)
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Illumina HiSeq 2000, ILLUMINA (1)
Gel-based experiment (1)
SWATH MS (1)

Instrument Platform

Illumina NovaSeq 6000 (10)
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MouseWG-6_V2_0_R1_11278593_A (3)
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Liquid Chromatography MS - positive - reverse phase (3)
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Illumina HiSeq 2000 (2)
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- (1)
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Gas Chromatography MS - positive - medium-polarity (1)
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Publication Date

2016 (74)
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2014 (61)
2013 (57)
2015 (55)
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2010 (43)
2012 (41)
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2011 (34)
2024 (30)
2008 (30)
2021 (29)
2020 (27)
2009 (27)
2018 (22)
2017 (19)
2019 (18)
2007 (11)
2006 (6)
2005 (6)
2004 (2)

CHEBI ID

CHEBI:17620 (3)
CHEBI:32080 (2)
CHEBI:140131 (2)
CHEBI:28847 (2)
CHEBI:2515 (2)
CHEBI:5301 (2)
CHEBI:42094 (2)
CHEBI:30764 (2)
CHEBI:5885 (2)
CHEBI:80845 (2)
CHEBI:6052 (2)
CHEBI:75633 (2)
CHEBI:16778 (2)
CHEBI:17226 (2)
CHEBI:18283 (2)
CHEBI:17992 (2)
CHEBI:15584 (2)
CHEBI:15864 (2)
CHEBI:36281 (2)
CHEBI:28635 (2)
CHEBI:18066 (2)
CHEBI:33508 (2)
CHEBI:16243 (2)
CHEBI:67486 (2)
CHEBI:90 (2)
CHEBI:16238 (2)
CHEBI:18388 (2)
CHEBI:17533 (2)
CHEBI:16750 (2)
CHEBI:28842 (2)

Metabolite Name

Benzoic acid (3)
Guanosine (3)
Parvisoflavanone (2)
Deoxyloganin (2)
Oleandolide (2)
Gentiopicrin (2)
Picrocrocin (2)
Glucose-1-phosphate (2)
Scopoletin (2)
Arbutin (2)
Phenylacetaldehyde (2)
Resveratrol (2)
Phenol (2)
Stigmasterol (2)
Pyruvic acid (2)
Umbelliferone (2)
2-C-Methyl-D-erythritol 4-phosphate (2)
Ferulic acid (2)
Uracil (2)
Epicatechin (2)
Spermine (2)
Pyroglutamic acid (2)
Magnoflorine (2)
Coniferyl aldehyde (2)
Gluconic acid (2)
Kynurenic acid (2)
Succinic acid (2)
Aconitic acid (2)
Maleic acid (2)
Apigenin (2)

IsPrivate

False (2)

Model Flag

Non Kinetic (2)

First Public Date

2022 (55)
2014 (49)
2026 (45)
2023 (42)
2025 (39)
2024 (33)
2021 (30)
2020 (21)
2015 (17)
2019 (16)
2018 (16)
2016 (9)
2017 (8)
2013 (4)

Modelling Approach

Logical model (2)

Study type

Transcription profiling by array (239)
RNA-seq of coding RNA (36)
ChIP-seq (22)
RNA-seq of non coding RNA (12)
Methylation profiling by array (11)
Comparative genomic hybridization by array (9)
Unknown experiment type (7)
Transcription profiling by SAGE (6)
Transcription profiling by RT-PCR (5)
RNA-seq of coding RNA from single cells (5)
ChIP-chip by tiling array (4)
Other (4)
Methylation profiling by high throughput sequencing (4)
MicroRNA profiling by array (2)
DNA-seq (2)
FAIRE-seq (1)
Cell line - Single-cell sequencing (1)
Human - High-throughput sequencing (1)
High-throughput sequencing (1)
Animal - High-throughput sequencing (1)
RNAi profiling by array (1)
Genotyping by array (1)
ATAC-seq (1)
Exome sequencing (1)
CUT&RUN (1)
RNA-seq of total RNA (1)

Release Date

2023 (83)
2022 (83)
2021 (79)
2014 (79)
2025 (76)
2016 (76)
2013 (72)
2015 (66)
2020 (59)
2024 (56)
2012 (52)
2019 (51)
2010 (47)
2018 (46)
2008 (42)
2011 (40)
2009 (39)
2017 (34)
2007 (20)
2026 (15)
2006 (13)
2005 (7)
2004 (5)
2002 (2)
1999 (2)
2003 (1)
2000 (1)

Lab affiliation

1. Gene Regulation, Stem Cells and Development group, PTS, Granada GENyO, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research, Avenida de la Ilustración 114, 18016 Granada, Spain. 2. Department of Biochemistry and Molecular Biology I, Faculty of Science, University of Granada, Avenida Fuentenueva s/n, 18071 Granada, Spain. 3. Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain. (1)
1. INSERM U1287, Université Paris-Saclay, Gustave Roussy Cancer Center, Villejuif, France 2. Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre, France (1)
1. Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3052, Victoria, Australia and Department of Medical Biology, The University of Melbourne, Royal Parade, Parkville, 3052, Victoria, Australia (1)
Biologics R&D Group/ Biomedical Program CSIRO Manufacturing Bayview Ave/ Research Way, Clayton, VIC3168 Australia (1)
Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai (1)
Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Research Institute for Medical Innovation, Nijmegen, The Netherlands. (1)
Department of Medical Oncology and Hematology, University and University Hospital Zurich, Zurich, Switzerland Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland (1)
Department of Molecular and Cellular Hemostasis Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands (1)
Department of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands (1)
Genome Biology Unit, EMBL Heidelberg (1)
Harry Perkins Institute of Medical Research and Centre of Excellence in Synthetic Biology, QEII Medical Centre, Nedlands, Western Australia 6009, Australia (1)
Institute of Innate Immunity Biomedical Center, 1OG011, University Hospitals, University of Bonn Venusberg-Campus 1, 53127 Bonn, Germany (1)
King's College London, British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences, London, UK (1)
Laboratory of mass spectrometry, Sanquin Research, Amsterdam, NL (1)
Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V. (1)
Molecular and Cellular Biology Baylor College of Medicine Houston, Texas (1)
STANFORD INSTITUTE FOR STEM CELL BIOLOGY AND REGENERATIVE MEDICINE, Stanford University, Stanford, CA, USA (1)
Sanquin Research (1)
Senior Lecturer in Transfusion Medicine / Consultant Haematologist, University of Cambridge / NHS Blood and Transplant, Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Puddicombe Way, Cambridge, CB2 0AW, United Kingdom (1)
Spanish National Cancer Research Center (CNIO) (1)
University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (1)

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Critical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation (Shotgun lipidomics assays without inhibition)

During megakaryopoiesis, megakaryocytes (MK) undergo cellular morphological changes with strong modification of membrane composition and lipid signaling. Here we adopt a lipid-centric multi-omics approach to create a quantitative map of the MK lipidome during maturation and proplatelet formation....

2023-07-26 | MTBLS6082 | MetaboLights

Critical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation (Targeted lipidomics assay without inhibition)

2023-07-26 | MTBLS6084 | MetaboLights

Critical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation (Shotgun lipidomics assays after inhibition with FSG67 and Triacsin C)

2023-07-26 | MTBLS6083 | MetaboLights

megamiR, microRNA expression profiles during megakaryocyte-erythrocyte progenitor (MEP) differentiation

This collection contains microRNA expression profiling data for samples purified from umbilical cord blood, belonging to one of the followiing populations: MEP, MEGA1, MEGA2, ERY1, ERY2, ERY3. MEP: megakaryocyte-erythrocyte precursors (defined by CD34+ CD38+ IL-3Ra- CD45RA- ); MEGA1: megakaryocyte p...

ORGANISM(S): Homo sapiens

2010-06-26 | E-GEOD-10593 | biostudies-arrayexpress

Osteomacs promote maintenance of murine hematopoiesis through megakaryocyte-induced upregulation of Embigin and CD166

Maintenance of hematopoietic stem cell (HSC) function in the niche is an orchestrated event. Osteomacs (OM), are key cellular components of the niche. Previously, we documented that osteoblasts, OM, and megakaryocytes interact to promote hematopoiesis. Here, we further characterize OM and identify m...

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

2024-01-11 | MSV000093840 | MassIVE

Transcription profiling of human tetraploid and polyploid (8N and 16N) megakaryocytes to identify genes which are up and down regulated during megakaryocyte differentiation/polyploidization

The aim of the experiment was to characterize by a pan-genomic approach genes which are continuously up and down regulated during polyploidization during megakaryocyte differentiation.

ORGANISM(S): Homo sapiens

2007-04-16 | E-TABM-133 | biostudies-arrayexpress

MicroRNA expression during murine fetal liver megakaryocyte differentiation

MicroRNAs are small non-coding RNAs that regulate cellular development by interfering with mRNA stability and translation. We defined the kinetics of global microRNA expression during the differentiation of murine hematopoietic progenitors into megakaryocytes. Of 435 miRNAs analyzed, 13 were upreg...

ORGANISM(S): Mus musculus

2010-12-07 | E-GEOD-22480 | biostudies-arrayexpress

Characterisation of the mouse megakaryocyte transcriptome

This study aims to identify all genes expressed in primary mouse megakaryocytes Keywords: Megakaryocyte, SAGE, transcriptome analysis Mouse megakaryocytes were grown in vitro from bone marrow progenitors. Mature, polyploid (approximately 95% 64n and 128n) differentiated megakaryocytes were used to ...

ORGANISM(S): Mus musculus

2007-02-02 | E-GEOD-6940 | biostudies-arrayexpress

Inducible Gata1 Suppression Expands Erythro-Megakaryocytic Progenitors from Embryonic Stem Cells

Embryonic stem (ES) and induced pluripotent stem (iPS) cells represent a potential source of megakaryocytes and platelets for transfusion therapies. However, most current ES/iPS cell differentiation protocols are limited by low yields of hematopoietic progeny. Mutations in the mouse and human genes ...

ORGANISM(S): Mus musculus

2015-12-09 | E-GEOD-66479 | biostudies-arrayexpress

Expression analysis of GATA1s murine megakaryocyte progenitors from bone marrow and fetal Liver

About 10% of Down syndrome (DS) infants are born with a myeloproliferative disorder (DS-TMD) that spontaneously resolves within the first few months of life. About 20-30% of these infants subsequently develop acute megakaryoblastic leukemia (DS-AMKL). In order to understand differences that may exis...

ORGANISM(S): Mus musculus

2013-03-29 | E-GEOD-45619 | biostudies-arrayexpress

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