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TranscriptomicsTranscription profiling of gonads from E14.5 megalin+/+ and megalin-/- embryos
Presently, genes regulated by steroid hormones during induced regression of the CSL (cranial suspensory ligament) are unknown. To identify such genes and to evaluate their expression levels in megalin-deficient mice, we performed global gene expression profiling on gonads from E14.5 megalin+/+ and m...
ORGANISM(S): Mus musculus 
2005-06-30 | E-MEXP-352 | biostudies-arrayexpress
ProteomicsPhospho proteomic on megalin during cell cycle stages
Mechanistic target of rapamycin (mTOR) signaling pathway controls eukaryotic growth by regulating metabolism, translation, autophagy and cell cycle. Genetic deletion of renal mTORC1 led to a Fanconi-like syndrome with reduction of the renal cortex, tubular epithelial transport and perturbation of th...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-05-26 | PXD071589 | Pride
Mtorc1 Megalin/lrp2 Phospho proteomics Cell cycle Proteolytic cleavage Endocytosis 
GenomicsSpns1 controls megalin dependent endocytosis via iron misregulation
Spns1 controls megalin dependent endocytosis via iron misregulation
PRJNA1118826 | ENA
ProteomicsRenal Proximal Tubule Cell-Specific Megalin Deletion Does Not Affect Atherosclerosis But Induces Tubulointerstitial Nephritis in Mice Fed a Western Diet
Female Lrp2 (megalin) f/f mice were bred with male Ndrg1-Cre ERT2 +/0 mice to develop PTC-LRP2 +/+ and PTC-LRP2-/- littermates. To study atherosclerosis, all mice were bred to an LDL receptor -/- background and fed a Western diet to induce atherosclerosis. PTC-specific megalin deletion did not atten...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-24 | PXD066759 | Pride
Atherosclerosis Megalin Tubulointerstitial Nephrititis Renal Mice 
GenomicsRenal Proximal Tubule Cell-specific Megalin Deletion Induces Tubulointerstitial Nephritis in Mice Fed Western Diet
Renal Proximal Tubule Cell-specific Megalin Deletion Induces Tubulointerstitial Nephritis in Mice Fed Western Diet
PRJNA1119377 | ENA
TranscriptomicsRenal Proximal Tubule Cell-specific Megalin Deletion Induces Tubulointerstitial Nephritis in Mice Fed Western Diet
Pharmacological inhibition of megalin (also known as low-density lipoprotein receptor-related protein 2: LRP2) attenuates atherosclerosis in hypercholesterolemic mice. Since megalin is abundant in renal proximal tubule cells (PTCs), PTC-LRP2 +/+ and -/- littermates in an LDL receptor -/- background ...
ORGANISM(S): Mus musculus 
2024-07-04 | GSE268879 | GEO
GenomicsTMAO Suppresses Megalin Expression and Albumin Uptake in Human Proximal Tubular Cells Via PI3K and ERK Signaling
TMAO Suppresses Megalin Expression and Albumin Uptake in Human Proximal Tubular Cells Via PI3K and ERK Signaling
PRJNA867154 | ENA
TranscriptomicsTMAO Suppresses Megalin Expression and Albumin Uptake in Human Proximal Tubular Cells Via PI3K and ERK Signaling
Trimethylamine-N-oxide (TMAO) is a uremic toxin, which has been associated with chronic kidney disease (CKD). Renal tubular epithelial cells play a central role in the pathophysiology of CKD. Megalin is an albumin-binding surface receptor on tubular epithelial cells, which is indispensable for urine...
ORGANISM(S): Homo sapiens 
2022-08-10 | GSE210692 | GEO
TranscriptomicsThe soluble intracellular domain of megalin does not affect renal proximal tubular function in vivo
The endocytic receptor megalin constitutes the main pathway for clearance of plasma proteins from the glomerular filtrate in the proximal tubules. However, little is know about the mechanisms that control receptor activity. A widely discussed hypothesis states that the intracellular domain (ICD) of ...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-19778 | biostudies-arrayexpress
TranscriptomicsThe soluble intracellular domain of megalin does not affect renal proximal tubular function in vivo
The endocytic receptor megalin constitutes the main pathway for clearance of plasma proteins from the glomerular filtrate in the proximal tubules. However, little is know about the mechanisms that control receptor activity. A widely discussed hypothesis states that the intracellular domain (ICD) of ...
ORGANISM(S): Mus musculus 
2011-01-01 | GSE19778 | GEO
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