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ProteomicsFAM69C functions as a kinase for eIF2α and promotes stress granule assembly
Stress granules are dynamic cytoplasmic ribonucleoprotein granules that assemble in response to cellular stress. Aberrant formation of stress granules has been linked to neurodegenerative diseases. However, the molecular mechanisms underlying the initiation of stress granules remain elusive. Here we...
ORGANISM(S): Homo sapiens (Human) 
2023-04-21 | PXD037697 | Pride
Eif2α  fam69c  inflammasome  stress response  stress granule. 
Metabolomics2E,4E-decadienoic acid, a novel anti-oomycete agent from co-culture of Bacillus subtilis and Trichoderma asperellum

Phytophthora nicotianae is an oomycete pathogen of global significance threatening many important crops. It is mainly controlled by chemosynthetic fungicides, which endangers ecosystem and human health; thus, there is an urgent need to explore alternatives for these fungicides. In this s...

2022-08-01 | MTBLS5405 | MetaboLights
MetabolomicsL-fucose and fucoidan alleviate high-salt diet-promoted acute inflammation

Excessive salt intake is a widespread health issue observed in almost every country around the world. A high salt diet (HSD) has a strong correlation with numerous diseases, including hypertension, chronic kidney disease and autoimmune disorders. However, the mechanisms underlying HSD-promotion o...

2024-02-21 | MTBLS9134 | MetaboLights
UnknownMeisoindigo Acts as a Molecular Glue to Target PKMYT1 for Degradation in Chronic Myeloid Leukemia Therapy.
Not available
S-EPMC12140364 | biostudies-literature
TranscriptomicsExpression data from shoot bases of rice seedling after gravistimulation
Upper and lower parts (flanks) of rice (Oryza sativa sp. japonica) shoot bases at 0.5 h and 6 h after gravistimulation was used for expression analysis in control and gravistimulated samples.Targets from biological replicates of both control and gravistimulated samples were generated and expression ...
ORGANISM(S): Oryza sativa Japonica Group 
2011-09-01 | E-GEOD-31834 | biostudies-arrayexpress
GenomicsTripartite organization of centromeric chromatin in budding yeast
The centromere is the genetic locus that organizes the proteinaceous kinetochore and is responsible for attachment of the chromosome to the spindle at mitosis and meiosis. In most eukaryotes, the centromere consists of highly repetitive DNA sequences that are occupied by nucleosomes containing the C...
ORGANISM(S): Saccharomyces cerevisiae 
2011-12-07 | E-GEOD-28298 | biostudies-arrayexpress
UnknownExposure-lag-response associations between weather conditions and ankylosing spondylitis: a time series study.
Not available
S-EPMC8314534 | biostudies-literature
TranscriptomicsTranscriptomics of Bacillus thuringiensis Strain CT-43.
We investigated the gene expression and metabolic regulatory mechanisms associated with the high-level accumulation of ICPs by performing the transcriptomics analysis of B. thuringiensis strain CT-43, using Illumina high throughout sequencing (RNA-seq) technique. The bacterial cells were collected a...
ORGANISM(S): Bacillus thuringiensis 
2013-04-17 | E-GEOD-39479 | biostudies-arrayexpress
MetabolomicsAnalysis of fecal microbiome and metabolome changes in goats with pregnant toxemia

Pregnancy toxemia is a common disease, which occurs in older ewes that are pregnant with multiple lambs in the third trimester. Most of the sick goats die within a few days, which can seriously impact the economic benefits of goat breeding enterprises. The disease is believed to be caused by maln...

2024-10-01 | MTBLS7519 | MetaboLights
UnknownGenetic diversity analysis of forty-three insertion/deletion loci for forensic individual identification in Han Chinese from Beijing based on a novel panel.
Not available
S-EPMC8913921 | biostudies-literature
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