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MetabolomicsL-fucose and fucoidan alleviate high-salt diet-promoted acute inflammation

Excessive salt intake is a widespread health issue observed in almost every country around the world. A high salt diet (HSD) has a strong correlation with numerous diseases, including hypertension, chronic kidney disease and autoimmune disorders. However, the mechanisms underlying HSD-promotion o...

2024-02-21 | MTBLS9134 | MetaboLights
TranscriptomicsTranscriptomic profiling of L-rhamnose utilization in Lmo0753 deletion mutant of Listeria monocytogenes EGDe from human foodborne outbreak associated lineage LII
Among the three major genetic lineages of L. monocytogenes (i.e. LI, LII, and LIII), LI and LII are predominantly associated with foodborne listeriosis outbreaks, whereas LIII is rarely implicated in human infections. In a previous study, we identified a Crp/Fnr family transcription factor lmo0753 t...
ORGANISM(S): Listeria monocytogenes 
2013-07-17 | E-GEOD-47721 | biostudies-arrayexpress
TranscriptomicsMEi vs BM-MSC
The aim of the experiment is to compare the transcriptional profile of MEi (mesenchymal-like mucoepidermoid tumor) cells with BM-MSCs (bone marrow mesenchymal stromal cells). The MEi cells were isolated from a mucoepidermoid tumor from the trachea. BM-MSCs were isolated from bone marrow of healthy d...
ORGANISM(S): Homo sapiens 
2015-01-20 | E-MTAB-2093 | biostudies-arrayexpress
TranscriptomicsIdentification of genes regulated by L-lactate and by DL-lactate in Lactobacillus plantarum
L. plantarum is known to possess an L-lactate inducible lactate racemase activity (Goffin et al. 2005. J. Bacteriol. 187:6750). In the present study, microarrays were used in order to identify all genes that are up-regulated by L-lactate, but not by a racemic mixture of D- and L-lactate. A mutant of...
ORGANISM(S): Lactobacillus plantarum 
2013-07-01 | E-GEOD-43518 | biostudies-arrayexpress
GenomicsChIPseq measurement of transcriptional engagement and replication stress at the Drosophila Mid-blastula Transition
These experiments measure genome-wide RNA Pol II binding in precisely staged wild-type embryos at five time points spanning the maternal to zygotic transition (nuclear cycles 12 through 14) of Drosophila melanogaster. In addition, RNA Pol II binding at nuclear cycle 13 is measured in embryos mutant ...
ORGANISM(S): Drosophila melanogaster 
2015-03-05 | E-GEOD-62925 | biostudies-arrayexpress
MetabolomicsHyperhomocysteinemia-related serum metabolome alterations not normalized by short-term folic acid treatment

Introduction

Hyperhomocysteinemia (HHCys) is an independent risk factor for various diseases such as cardiovascular diseases, Alzheimer's, and cancers. Folate deficiency is one of the significant reasons for HHCys. However, it is not known whether folate deficiency with HHCys is associated w...
2022-02-07 | MTBLS2150 | MetaboLights
UnknownMechanistic insights into endometriosis: roles of Streptococcus agalactiae and L-carnitine in lesion development and angiogenesis.
Not available
S-EPMC12198069 | biostudies-literature
TranscriptomicsDanio rerio larvae exposed to SSRIs Fluoxetine and Sertraline
Pharmaceutical chemicals used in human medicine are released into surface waters via municipal effluents and pose a risk for aquatic organisms. Among these substances are selective serotonin reuptake inhibitors (SSRIs) which can affect aquatic organisms at sub ppb concentrations. To better underst...
ORGANISM(S): Danio rerio 
2012-09-06 | E-GEOD-31712 | biostudies-arrayexpress
Transcriptomicsmature piRNAs expression profile in human bronchial epithelial (HBE) and non-small cell lung cancer (NSCLC) cells
To elucidate potential roles of piRNA in lung cancer, we analyzed global piRNA expression profiles in 8 NSCLC and 3 HBE cell lines. RNA-seq results showed that >99% of the approximately 4.5 million reads were between 26 and 32 bases. Most of the piRNA loci are represented by two or more identical re...
ORGANISM(S): Homo sapiens 
2016-06-27 | E-GEOD-57681 | biostudies-arrayexpress
ProteomicsAKT Inhibition Promotes Non-autonomous Cancer Cell Survival [Antibody Arrays (L-507)]
Small-molecule inhibitors of AKT signaling are being in evaluated in patients with various cancer types, but have so far proven therapeutically disappointing for reasons that remain unclear. Here, we treat cancer cells with sub-therapeutic doses of Akti-1/2, an allosteric small molecule AKT inhibito...
ORGANISM(S): Homo sapiens 
2015-12-09 | E-GEOD-71892 | biostudies-arrayexpress
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