Danio rerio larvae exposed to SSRIs Fluoxetine and Sertraline

ABSTRACT: Pharmaceutical chemicals used in human medicine are released into surface waters via municipal effluents and pose a risk for aquatic organisms. Among these substances are selective serotonin reuptake inhibitors (SSRIs) which can affect aquatic organisms at sub ppb concentrations. To better understand biochemical pathways influenced by SSRIs, evaluate changes in the transcriptome, and identify gene transcripts with potential for biomarkers of exposure to SSRIs; larval zebrafish Danio rerio were exposed (96 h) to two concentrations (25 and 250 µg/L) of the SSRIs, fluoxetine and sertraline, and changes in global gene expression were evaluated (Affymetrix GeneChip® Zebrafish Array). Significant changes in gene expression (>=1.7 fold change, p<0.05) were determined with Partek® Genomics Suit

ORGANISM(S): Danio rerio

SUBMITTER: Julia Gouffon 

PROVIDER: E-GEOD-31712 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress