Effects of bisphenol A on ovarian gene expression in fathead minnows and zebrafish [FHM data set]

ABSTRACT: Effects of bisphenol A (BPA) on ovarian transcript profiles as well as targeted endpoints with endocrine/reproductive relevance were examined in two fish species, fathead minnow (Pimephales promelas) and zebrafish (Danio rerio), exposed in parallel using matched experimental designs. Four days of waterborne exposure to 10 µg BPA caused significant vitellogenin induction in both species. However, zebrafish were less sensitive to effects on hepatic gene expression and steroid production than fathead minnow and the magnitude of vitellogenin induction was more modest. The concentration-response at the ovarian transcriptome level was non-monotonic and violated assumptions that underlie proposed methods for estimating hazard thresholds from transcriptomic results. However, the non-monotonic prof

ORGANISM(S): Pimephales promelas

SUBMITTER: Dan Villeneuve 

PROVIDER: E-GEOD-28353 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress