Global ovary gene interaction network structure informs biological effects of Chemical stressors

ABSTRACT: Background: Complex biological networks control fundamental processes such as reproduction. The relationship of network structure to biological function was investigated in a global gene interaction network developed from ovary tissues of the model fish, fathead minnow (Pimephales promelas). Results: A global ovary gene interaction network was inferred from gene expression in ovaries of fathead minnow representing 288 different exposure conditions and 1,472 microarrays. More than 74 percent of the interactions in two subnetworks and 37% of the connections in a third subnetwork were also present as known connections found in curated databases and the literature. Subnetworks within the network were enriched in specific pathways and key ovarian functions. The network location of differentiall

ORGANISM(S): Pimephales promelas

SUBMITTER: Natalia Vinas 

PROVIDER: E-GEOD-70936 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress