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GenomicsGenome-wide profiling of CTCF binding (ChIP-seq) in A549 and U2OS cells
To identify genome-wide CCCTC binding factor (CTCF)-binding in A549 (ATCC CCL-185) and U2OS cells stably expressing rat GR (Rogatsky et al. , Mol Cell Biol, 1997. 17(6): p. 3181-93.) we performed ChIP-seq experiments upon hormone treatment (1.5 h, 1 M dexamethasone).
ORGANISM(S): Homo sapiens 
2018-04-12 | E-MTAB-5352 | biostudies-arrayexpress
ProteomicsIdentification and characterization of DNA sequences that restrict genomic binding of the glucocorticoid receptor
The glucocorticoid receptor (GR), is a hormone-activated transcription factor which binds to GR binding sequences (GBS) encoded in the genome. Interestingly, of the many genomic sequences matching the GR consensus sequence only a small subset is actually bound. This indicates that the presence of a...
ORGANISM(S): Homo sapiens (Human) 
2016-03-30 | PXD002252 | Pride
Glucocorticoid receptor Negative regulatory sequences Dna binding 
GenomicsGenome-wide profiling of H3K27ac (ChIP-seq) in IMR90 cells
To determine the genome-wide pattern of H3K27ac in IMR90 (ATCC CCL-186) cells we performed ChIP-seq upon hormone treatment (1.5 h, 1 M dexamethasone).
ORGANISM(S): Homo sapiens 
2018-04-12 | E-MTAB-5355 | biostudies-arrayexpress
TranscriptomicsCircularized chromosome conformation capture (4C-seq) in A549 and U2OS cells stably expressing rat GR
To investigate the interaction landscape at the GILZ locus we performed 4C-seq in A549 (ATCC CCL-185) and U2OS cells stably expressing rat GR (Rogatsky et al. , Mol Cell Biol, 1997. 17(6): p. 3181-93.) upon hormone treatment (1.5 h, 1 M dexamethasone). Experiments were performed in two biological re...
ORGANISM(S): Homo sapiens 
2018-04-12 | E-MTAB-5350 | biostudies-arrayexpress
GenomicsGlucocorticoid receptor profiling in U2OS cells expressing GRalpha or GRgamma isoform
To determine whether insertion of a single amino acid had an effect on Glucocorticoid receptor (GR) occupancy, we performed ChIP-seq of GRalpha and GRgamma in the same U2OS osteosarcoma cell lines, upon glucocorticoid treatment. These assays are also part of submission E-MTAB-2955
ORGANISM(S): Homo sapiens 
2014-08-08 | E-MTAB-2731 | biostudies-arrayexpress
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