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ModelsRay2013 - Meiotic initiation in S. cerevisiae
Ray2013 - Meiotic initiation in S. cerevisiae A mathematical representation of early meiotic events, particularly feedback mechanisms at the system level and phosphorylation of signalling molecules for regulating protein activities, is described here Th...
2024-09-02 | BIOMD0000000626 | BioModels
TranscriptomicsMeiotic DNA double strand breaks in the yeast Saccaromyces cerevisiae
DNA double-strand breaks (DSBs) initiate meiotic recombination. Past DSB-mapping studies have used rad50S or sae2? mutants, which are defective in break processing, to accumulate DSBs, and report large (= 50 kb) “DSB-hot” regions that are separated by “DSB-cold” domains of similar size. Substantial ...
ORGANISM(S): Saccharomyces cerevisiae 
2007-12-30 | E-GEOD-8981 | biostudies-arrayexpress
TranscriptomicsSeparation of DNA replication from the assembly of break-competent meiotic chromosomes
The meiotic cell division reduces the chromosome number from diploid to haploid to form gametes for sexual reproduction. Although much progress has been made in understanding meiotic recombination and the two meiotic divisions, the processes leading up to recombination, including the prolonged pre-m...
ORGANISM(S): Saccharomyces cerevisiae 
2012-06-14 | E-GEOD-35667 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila melanogaster spermatogenesis: mitotic, meiotic and post-meiotic cells
We conducted a genome-wide expression analysis of wild-type males using three cell populations isolated from mitotic, meiotic and post-meiotic phases of spermatogenesis in Drosophila melanogaster. Our approach was to directly isolate testis regions enriched with RNAs from each of the three specific ...
ORGANISM(S): Drosophila melanogaster 
2009-11-28 | E-GEOD-18502 | biostudies-arrayexpress
TranscriptomicsMeiotic recombination cold spots in chromosomal cohesion sites [ChIP-chip]
Meiotic chromosome architecture called M-bM-^@M-^\axis-loop structuresM-bM-^@M-^] and histone modifications have been demonstrated to regulate the Spo11-dependent formation of DNA double-strand breaks (DSBs) that trigger meiotic recombination. Using genome-wide chromatin immunoprecipitation (ChIP) a...
ORGANISM(S): Schizosaccharomyces pombe 
2014-03-31 | E-GEOD-52858 | biostudies-arrayexpress
TranscriptomicsRec8 guides canonical Spo11 distribution along yeast meiotic chromosomes
Spo11-mediated DNA double strand breaks (DSBs) that initiate meiotic recombination are temporally and spatially controlled. The meiotic cohesin Rec8 has been implicated in regulating DSB formation, but little is known about the features of their interplay. To shed light on this point, we investigate...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-18 | E-GEOD-8422 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae mre11, rad50 and spo11 mutants in premeiosis and meiotic prophase
Mre11, together with Rad50 and Xrs2/NBS, plays pivotal roles in homologous recombination, repair of DNA double strand breaks (DSBs), activation of damage-induced checkpoint, and telomere maintenance. Using DNA microarray assays to analyze yeast mutants (mre11delta, rad50delta, and spo11Y135F) defect...
ORGANISM(S): Saccharomyces cerevisiae 
2007-10-23 | E-GEOD-6620 | biostudies-arrayexpress
TranscriptomicsMeiotic time-course expression profile
To investigate the dynamics of the meiotic transcriptome and to ensure meiotic synchrony of our samples, we measured RNA abundance in vegetative cells, respiratory (pre-meiotic) cells and in synchronously sporulating cells at various times after transfer to sporulation media (SM). SK1 yeast strain S...
ORGANISM(S): Saccharomyces cerevisiae SK1 
2010-05-22 | E-GEOD-18181 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and mei4 knock-out fission yeast to identify genes that are activated during meiosis
To identify genes that are activated during meiosis and tell the effect of mei4 on different genes at 0 and 5 hours after meiotic induction.
ORGANISM(S): Schizosaccharomyces pombe 
2008-09-26 | E-TABM-465 | biostudies-arrayexpress
TranscriptomicsMapping of meiotic double-strand break (DSB) sites and DSB factor association near repetitive DNA elements in S. cerevisiae
DNA double strand breaks (DSBs) in repetitive sequences are a potent source of genomic instability, due to the possibility of non-allelic homologous recombination (NAHR). Repetitive sequences are especially at risk during meiosis, when numerous programmed DSBs are introduced into the genome to initi...
ORGANISM(S): Saccharomyces cerevisiae 
2011-08-14 | E-GEOD-30073 | biostudies-arrayexpress
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