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TranscriptomicsAssociation of maternal mRNA with the spindle in mouse oocytes
The oocytes of many species, both invertebrate and vertebrate, contain a large collection of localized determinants in the form of proteins and translationally inactive maternal mRNAs. However, it is unknown whether mouse oocytes contain localized MmRNA determinants and what mechanisms might be resp...
ORGANISM(S): Mus musculus 
2013-11-06 | E-GEOD-46875 | biostudies-arrayexpress
ProteomicsNcd regulation reveals a new mechanism for targeting proteins to the meiotic spindle in oocytes
The meiotic spindle in oocytes is formed without centrosomes. How a bipolar spindle is assembled and maintained around chromosomes in oocytes remains to be established. Multiple kinases are known to regulate the meiotic spindle, but how they execute their function is poorly understood. We found t...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2017-08-29 | PXD006080 | Pride
Ncd regulation Oocytes Shotgun proteomics Meiotic spindle Drosophila Meiosis 
UnknownSpindle tubulin and MTOC asymmetries may explain meiotic drive in oocytes.
Not available
S-EPMC6063951 | biostudies-literature
ProteomicsMolecular Basis of Spindle Morphology Changes at the Meiosis to Mitosis Transition
The transition from meiotic divisions in the oocyte to mitotic divisions in the early embryo is a critical step in animal development. Despite negligible changes to cell size, shape, and content, following fertilization the small, barrel-shaped meiotic spindle is replaced by a large zygotic spindle ...
ORGANISM(S): Xenopus Laevis (ncbitaxon:8355) 
2024-07-04 | MSV000095250 | MassIVE
ProteomicsSpecialisation of meiotic kinetochores revealed through a synthetic spindle assembly checkpoint strategy.
Meiosis creates haploid gametes through two sequential M phases. While many studies have focused on meiosis I, the molecular events which drive and define meiosis II are largely unknown. Here, we report a novel cell synchronization strategy which allows for collection of yeast cells arrested at meta...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-03-04 | PXD067911 | Pride
UnknownKatanin controls mitotic and meiotic spindle length.
Not available
S-EPMC2064698 | biostudies-literature
GenomicsPrefoldin is critical for meiotic spindle function, revealing coupling between chromosome segregation and cellular remodeling
Prefoldin is critical for meiotic spindle function, revealing coupling between chromosome segregation and cellular remodeling
PRJNA1389638 | ENA
UnknownRNF20 Regulates Oocyte Meiotic Spindle Assembly by Recruiting TPM3 to Centromeres and Spindle Poles.
Not available
S-EPMC10987117 | biostudies-literature
ProteomicsEchinoderm microtubule-associated protein 1 is indispensable for oocyte spindle assembly and meiotic progression in mice
proteins from immunoprecipitation (IP) of EML1 indentified by mass spectrometry
ORGANISM(S): Homo Sapiens 
PXD025159 |
ProteomicsPhosphosites of the yeast centrosome component Spc110 contribute to mitotic exit
Spc110 is an essential component of the spindle pole body (SPB), the yeast equivalent of the centrosome, that recruits the gamma-tubulin complex to the nuclear side of SPB to form the mitotic spindle. Here we identify two phosphosites (S11 and S36) in old (from maternal origin) Spc110. Yeast expres...
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2023-04-03 | PXD033085 | JPOST Repository
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