Sort   by:  
 Page size 
MetabolomicsGut microbiota-modulated glutamic acid rejuvenates the quality of oocytes deteriorated by advanced reproductive age

The gut microbiota plays a vital role in maintaining the physiological function of host health and the pathogenesis of various diseases. However, its relationship with maternal age-associated decline in oocyte quality remains elusive. Here, we report that establishment of gut microbiota from youn...

2026-05-07 | MTBLS14062 | MetaboLights
MetabolomicsNorgestrel exposure accelerated the abnormal occurrence of germinal vesicle breakdown and triggered damage to cellular structure and function in oocytes of the Pacific oyster (Crassostrea gigas)

Progestins are ubiquitous in aquatic environments, with adverse effects on aquatic organisms' reproduction even at extremely low concentrations (0.8 ng/L). As female germ cells, oocytes play an irreplaceable role in organismal reproductive processes. However, the toxic mechanism of norgestrel (NG...

2025-09-10 | MTBLS12976 | MetaboLights
ProteomicsDIA-based protein quantification of mouse oocytes from five developmental stages.
The oocytes in 6 replicates from five stages were analyzed using DIA-based protein quantification technology.
ORGANISM(S): Mus musculus (Mouse) 
2025-01-29 | PXD050840 | Pride
Mouse oocytes Dia 
TranscriptomicsGene expression profile of Dicer-deficient oocytes
Small RNAs, such as miRNAs and siRNAs, are involved in gene regulation in a variety of systems, including mouse oocytes. Dicer is a ribonuclease III enzyme essential for miRNA and siRNA biosynthesis. In an effort to uncover the function of small RNAs during oocyte growth, we specifically deleted Dic...
ORGANISM(S): Mus musculus 
2010-04-06 | E-GEOD-17985 | biostudies-arrayexpress
ProteomicsQuantitative proteomics analysis of RPL12 mutant and WT mouse oocytes
RPL12 mutant MII oocytes in 5 replicates and wildtype control in 6 replicates were analyzed using DIA-based protein quantification technology.
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD050652 | Pride
Quantitative proteomics Mouse Rpl12 Dia Oocyte 
TranscriptomicsPiwi proteins and piRNAs in mammalian oocytes and early embryos
Germ cells of most animals critically depend on piRNAs and Piwi proteins. Surprisingly, piRNAs in mouse oocytes are relatively rare and dispensable. We present compelling evidence for strong Piwi-piRNA expression in oocytes of other mammals. Human fetal oocytes express PIWIL2 and transposon-enriched...
ORGANISM(S): Macaca fascicularis 
2015-03-27 | E-GEOD-64942 | biostudies-arrayexpress
ProteomicsProteomic-based identification of oocyte maturation-related proteins in mouse GV oocytes
In this study, we applied 1D SDS-PAGE and RP-LC-MS/MS to investigate the proteins stored in GV mouse oocytes. This high-performance strategy allowed us to define a set of 1405 different mouse GV oocyte proteins. It is confirmed that this study will help us to understand the diverse biological proces...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-17 | PXD014314 | Pride
Mouse Gv oocytes Lc-ms/ms 
ProteomicsQuantitative proteomic analysis of oocytes from high-fat diet (HFD)-fed and normal diet mice
In order to establish an obese mouse model, female mice were continuously fed with a high-fat diet (HFD) or a normal diet (control) for 16 weeks beginning at three weeks of age. In this paper, these mice are termed ‘HFD mice’ and ‘control mice’, respectively. Accordingly, we call their oocytes ‘HFD ...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-24 | PXD006641 | Pride
Oocytes Quantitative High-fat diet Hfd 
TranscriptomicsTranscription profiling of mouse oocytes reveals abundant transcripts from retrotransposons are unstable
One physiological function proposed for RNA interference (RNAi) is to constrain expression of repetitive elements and thereby reduce the incidence of retrotransposition. Consistent with this model is that inhibiting the RNAi pathway results in an increase in expression of repetitive elements in pre...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4508 | biostudies-arrayexpress
ProteomicsMammalian oocytes store proteins in cytoplasmic lattices
Oocytes must accumulate and store maternal factors such as proteins during growth to sustain the first stages of embryonic development. How mammalian oocytes store maternal proteins is not understood. Here, we show that mouse and human oocytes store proteins on cytoplasmic lattices. With super-resol...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-23 | PXD038575 | Pride
Dia Cytoplasmic lattices Oocytes Lc-ms/ms 
Sort   by:  
 Page size