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TranscriptomicsmicroRNAs distinguish cytogenetic subgroups in pediatric AML and contribute to complex regulatory networks in AML-relevant pathways
microRNAs, important regulators of cell proliferation and apoptosis, have been shown to be involved in the pathogenesis of acute myeloid leukemia in adulthood AML. However, comprehensive studies in AML of children and adolescents are missing so far. We investigated the miRNA expression profiles of d...
ORGANISM(S): Homo sapiens 
2013-09-11 | E-GEOD-35320 | biostudies-arrayexpress
TranscriptomicssiRNA profiling of HeLa cells reveals strand-specific 5-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity.
Small interfering RNAs (siRNAs) and microRNAs (miRNAs) guide catalytic sequence-specific cleavage of fully or nearly fully complementary target mRNAs or control translation and/or stability of many mRNAs that share 6-8 nucleotides (nt) of complementarity to the siRNA and miRNA 5' end. siRNA- and miR...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-10960 | biostudies-arrayexpress
GenomicsChIP-Seq of human endogenous small RNAs associated to Argonaute 1 and 2
Small non-coding RNAs function in concert with Argonaute (Ago) proteins to regulate gene expression at the level of transcription, mRNA stability or translation. Ago proteins bind small RNAs and form the core of silencing complexes. Here we report the analysis of small RNAs associated with human ...
ORGANISM(S): Homo sapiens 
2008-11-20 | E-GEOD-13370 | biostudies-arrayexpress
TranscriptomicsA miR-155-ruled microRNA hierarchy in dendritic cell maturation and macrophage activation
MicroRNAs (miRNAs) are small RNAs that play important regulatory roles in many cellular pathways. MiRNAs associate with members of the Argonaute (Ago) protein family and bind to partially complementary sequences on mRNAs and induce translational repression or mRNA decay. MiRNA expression can be cont...
ORGANISM(S): Mus musculus 
2014-01-03 | E-GEOD-48404 | biostudies-arrayexpress
TranscriptomicsConservation-independent identification of novel miRNAs
Motivation: MicroRNAs (miRNAs) are short regulatory RNAs derived from a longer precursor RNA. miRNA biogenesis has been studied in animals and plants, recently elucidating more diverse and complex aspects, such as non-conserved, speciesspecific, and heterogeneous miRNA precursor populations. Small R...
ORGANISM(S): Volvox carteri 
2016-03-02 | E-GEOD-58703 | biostudies-arrayexpress
TranscriptomicsIdentification and analysis of expression of novel microRNAs of murine gammaherpesvirus 68
Murine gammaherpesvirus 68 (MHV-68) is closely related to Epstein-Barr virus (EBV) and KaposiM-bM-^@M-^Ys sarcoma-associated herpesvirus (KSHV) and provides a small animal model to study the pathogenesis of gammaherpesvirus (M-NM-3HV) infections. To completely explore the potential of the MHV-68 sys...
ORGANISM(S): Mus musculus 
2010-07-15 | E-GEOD-22938 | biostudies-arrayexpress
TranscriptomicsIdentification of KSHV, EBV and cellular miRNA targets in human B-cells using RIP-Chip
RIP-Chip was performed on DG75-eGFP, DG75-10/12, BCBL-1, BL41, BL41 B95.8 and Jijoye using anti-human Ago2 (11A9) antibodies. Anti-BrdU antibodies were used as controls for DG75-eGFP, DG75-10/12 and BCBL-1. Total RNA was used as control for BL41, BL41 B95.8 and Jijoye. Samples were analyzed on Affym...
ORGANISM(S): Homo sapiens 
2011-02-04 | E-GEOD-17180 | biostudies-arrayexpress
TranscriptomicsIdentification of miRNAs regulated by TGF-b in human CD8+ T cells (small RNA-seq)
The goal of the current study was to identify miRNAs regulated by TGF-b in human CD8+ T cells and analyze the function of these miRNAs in shaping the immunomodulatory effect of TGF-b in these cells. We identified the miR-23a cluster to be upregulated and found that this cluster could target key mole...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-46322 | biostudies-arrayexpress
TranscriptomicsIdentification of novel Epstein-Barr Virus miRNA genes from Nasopharyngeal Carcinomas
MicroRNAs (miRNAs) represent a conserved class of small non-coding RNAs that are found in all higher eukaryotes as well as some DNA viruses. MiRNAs are 20-25 nucleotides (nt) in length and have important regulatory functions in biological processes such as embryonic development, cell differentiation...
ORGANISM(S): Homo sapiens 
2009-02-07 | E-GEOD-14738 | biostudies-arrayexpress
TranscriptomicsGenome-wide miRNA-expression analysis after p53 activation in colorectal cancer cells
In order to comprehensively identify miRNA-expression changes after p53-activation a miRNA-Seq analysis was conducted after activation of a conditional p53 allele in SW480 cells. SW480/pRTR-p53-VSV cells were subjected to miRNA-Seq analysis after 16 hours doxycycline-treatment. Kompetenzzentrum für ...
ORGANISM(S): Homo sapiens 
2015-07-21 | E-GEOD-67181 | biostudies-arrayexpress
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