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TranscriptomicsA miR-155-ruled microRNA hierarchy in dendritic cell maturation and macrophage activation
MicroRNAs (miRNAs) are small RNAs that play important regulatory roles in many cellular pathways. MiRNAs associate with members of the Argonaute (Ago) protein family and bind to partially complementary sequences on mRNAs and induce translational repression or mRNA decay. MiRNA expression can be cont...
ORGANISM(S): Mus musculus 
2014-01-03 | E-GEOD-48404 | biostudies-arrayexpress
TranscriptomicsGene expression profile of cell lines 2106T, H1975 and MeWo after knockdown of PAEP.
Gene expression profile was analyzed after knockdown of PAEP in lung cancer cell lines 2106T and H1975 as well as in skin cancer cell line MeWo. The aim of the study was to investigate the role of PAEP and its protein product glycodelin in lung cancer cell lines. Cells were treated with a control si...
ORGANISM(S): Homo sapiens 
2015-04-22 | E-GEOD-60888 | biostudies-arrayexpress
TranscriptomicsComparative gene expression analysis of mesenchymal stem cells (MSC) derived from non-small cell lung cancer (NSCLC) and corresponding normal lung tissue (NLT)
The stromal microenvironment plays a vital role in cancer initiation and progression. We performed a comparative expression profiling of pulmonary MSC derived from NSCLC and corresponding normal lung tissue of 5 newly diagnosed patients. The analysis indicated variable expression of genes involved i...
ORGANISM(S): Homo sapiens 
2013-02-07 | E-GEOD-23066 | biostudies-arrayexpress
TranscriptomicsVALIDATION STUDY TO VERIFY DIAGNOSTIC MARKERS FOR LUNG CANCER IN ENDOBRONCHIAL LINING FLUID
We investigated whether biomarker analysis in endobronchial epithelial lining fluid (ELF) collected by bronchoscopic microsampling may be useful for a definitive preoperative diagnosis. Therefore we compared ELF samples close to nodule and from the contralateral site from patients with malignant or ...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-27553 | biostudies-arrayexpress
TranscriptomicsEstablishment and Comparative Characterization of Novel Non-Small Cell Lung Cancer Cell Lines and Their Corresponding Tumor Tissue
Cell lines play an important role for studying tumor biology and novel therapeutic agents. We demonstrated that cell lines represent a useful and reliable in vitro system for studying basic mechanisms in lung cancer. Moreover, we presented 3 novel, comprehensively characterized SCC cell lines. Estab...
ORGANISM(S): Homo sapiens 
2011-08-30 | E-GEOD-25251 | biostudies-arrayexpress
TranscriptomicsSCREENING STUDY TO IDENTIFY DIAGNOSTIC MARKERS FOR LUNG CANCER IN ENDOBRONCHIAL LINING FLUID
We investigated whether biomarker analysis in endobronchial epithelial lining fluid (ELF) collected by bronchoscopic microsampling may be useful for a definitive preoperative diagnosis. Therefore we compared ELF samples close to nodule and from the contralateral site from patients with malignant or ...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-27489 | biostudies-arrayexpress
UnknownGenome-Wide DNA Methylation Analysis Reveals Epigenetic Dysregulation of MicroRNA-34A in TP53-Associated Cancer Susceptibility.
Not available
S-EPMC6366343 | biostudies-literature
TranscriptomicsIntratumor heterogeneity of gene expression profiles in early stage non-small cell lung cancer (NSCLC)
Gene expression profiling of NSCLC tissues let to the establishment of several prognostic, predictive gene signatures with little overlap. To study factors introducing variability into gene expression microarray studies we compared interpatient (patient-to-patient) and intrapatient (tumor sub-sample...
ORGANISM(S): Homo sapiens 
2014-09-23 | E-GEOD-33532 | biostudies-arrayexpress
Genomicsena-DATASET-DKFZ-29-05-2020-15:56:12:496-205 - samples
ALI culture bronchial cells and alveolar lung surgical resection scRNA-Seq
EGAD00001006185 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
GenomicsSARS‐CoV‐2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells
The SARS‐CoV‐2 pandemic affecting the human respiratory system severely challenges public health and urgently demands for increasing our understanding of COVID‐19 pathogenesis, especially host factors facilitating virus infection and replication. SARS‐CoV‐2 was reported to enter cells via binding to...
EGAS00001004419 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
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