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TranscriptomicsThe transcription factor Amr1 induces melanin biosynthesis and suppresses virulence in Alternaria brassicicola
Alternaria brassicicola is a successful saprophyte and necrotrophic plant pathogen. Several A. brassicicola genes have been characterized as virulence factors affecting pathogenesis of Brassica species. To study regulatory mechanisms of pathogenesis, we mined 421 genes in silico encoding putative ...
ORGANISM(S): Alternaria brassicicola 
2013-02-19 | E-GEOD-36781 | biostudies-arrayexpress
TranscriptomicsCandida albicans DOPA-grown cells
The fungal pathogen Candida albicans produces dark-pigmented melanin when grown in a basal medium containing 1 mM l-DOPA as melanin substrate. In the widely used C. albicans strain SC5314, melanin appeared after 3-4 days of incubation in l-DOPA medium. The experiment was designed to reveal cadidat...
ORGANISM(S): Candida albicans 
2010-07-07 | E-GEOD-20338 | biostudies-arrayexpress
ProteomicsIntegrative Proteome and Metabolomics Analyses of Cryptococcus neoformans Responses to Melanin Substrates Niger seed and L-DOPA
Melanin, as a pivotal antioxidant pigment, plays a critical role in the pathogenicity of Cryptococcus neoformans. However, the underlying signaling pathways responsible for melanin biosynthesis in C. neoformans are not yet fully elucidated. In this study, proteome and metabolomics analyses were cond...
ORGANISM(S): Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 
2025-07-23 | PXD056054 | Pride
Cryptococcus neoformans  melanin biosynthesis  substrate-dependent manner  substrate-independent manner 
ProteomicsDepletion of melanin exposes Aspergillus flavus conidial surface proteins and alters the surface architecture and virulence.
A. flavus keratitis is one of the predominant fungal infections affecting the tropical parts of the world. Melanin is a virulence factor in numerous pathogenic fungi and the melanin layer maintains the cell wall structure and provides chemical and physical protection to the organism. However, the mo...
ORGANISM(S): Aspergillus flavus FRR 3643 
2024-05-23 | PXD037707 | Pride
Non-melanized conidia Melanized conidia Melanin And surface protein 
UnknownEffects of Aging on Hair Color, Melanosomes, and Melanin Composition in Japanese Males and Their Sex Differences.
Not available
S-EPMC9693441 | biostudies-literature
GenomicsTranscriptomic profiles of melanin pigmentation in a plumage ornament
Transcriptomic profiles of melanin pigmentation in a plumage ornament
PRJNA702979 | ENA
ProteomicsAspergillus fumigatus melanin manipulates the cargo and kinetics of neutrophil-derived extracellular vesicles
Neutrophil-derived extracellular vesicles have regained scientific interest as potent ‘wireless’ modulators with pleiotropic effects on the immune system. A few studies have addressed their role in the context of microbial pathogenesis showing their bacteriostatic effects against Staphylococcus aure...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) 
2019-05-17 | PXD005994 | Pride
Antifungal extracellular vesicles Aspergillus fumigatus Melanin Neutrophils 
UnknownBiotechnological Production and Characterization of Extracellular Melanin by Streptomyces nashvillensis.
Not available
S-EPMC10892051 | biostudies-literature
GenomicsUnravelling of the novel melanin biosynthesis-signalling networks in Cryptococcus neoformans
Unravelling of the novel melanin biosynthesis-signalling networks in Cryptococcus neoformans
PRJNA545271 | ENA
MetabolomicsImaginal disc growth factor maintains cuticle structure and controls melanization in the spot pattern formation of Bombyx mori

The complex stripes and patterns of insects play key roles in behavior and ecology. However, the fine-scale regulation mechanisms underlying pigment formation and morphological divergence remain largely unelucidated. Here we demonstrated that imaginal disc growth factor (IDGF) maintains cuticle s...

2020-09-20 | MTBLS1825 | MetaboLights
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