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ProteomicsPolianthes tuberosa L. Extract Suppresses Melanogenesis through Concurrent Inhibition of cAMP/CREB and MAPK Signaling Pathways
Ultraviolet (UV) radiation is a primary environmental stimulus for skin hyperpigmentation. Polianthes tuberosa L. (PT), rich in polyphenols and flavonoids, possesses antioxidant and anti-inflammatory properties, yet the anti-melanogenic mechanism of the PT extract (PTE) remains unexplored. Network p...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-16 | PXD072752 | Pride
Anti-melanogenesis  hyperpigmentation  mechanistic study  oxidative stress  polianthes tuberosa l. flower 
TranscriptomicsIL-17 and TNF synergistically induce growth-associated cytokines in melanocytes while suppressing melanogenesis
In this study, we sought to determine how IL-17 and TNF influence normal human melanocytes, either alone, or with both cytokines together. We reveal a dichotomous effect of IL-17 and TNF, which not only elicit essential mitogenic cytokines but also suppress melanogenesis by down-regulating genes of...
ORGANISM(S): Homo sapiens 
2013-06-15 | E-GEOD-40413 | biostudies-arrayexpress
GenomicsHeat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway
Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway
PRJNA956578 | ENA
UnknownStress chaperone mortalin regulates human melanogenesis.
Not available
S-EPMC4907994 | biostudies-literature
TranscriptomicsIL-17 and TNF synergistically induce growth-associated cytokines in melanocytes while suppressing melanogenesis
In this study, we sought to determine how IL-17 and TNF influence normal human melanocytes, either alone, or with both cytokines together. We reveal a dichotomous effect of IL-17 and TNF, which not only elicit essential mitogenic cytokines but also suppress melanogenesis by down-regulating genes of ...
ORGANISM(S): Homo sapiens 
2013-06-15 | GSE40413 | GEO
TranscriptomicsHeat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway
Global warming and rising temperature significantly increase the incidence of heat stress, which is known to affect the process of inflammation and aging. However, the effect of heat stress on skin melanogenesis is not fully known. We found that healthy foreskin tissues underwent significant pigment...
ORGANISM(S): Homo sapiens 
2023-05-20 | GSE229915 | GEO
UnknownDimethyl Itaconate Inhibits Melanogenesis in B16F10 Cells.
Not available
S-EPMC10045371 | biostudies-literature
GenomicsInvestigating the function of Sox10 in avian melanogenesis
Investigating the function of Sox10 in avian melanogenesis
PRJNA1039612 | ENA
UnknownThe role of melanogenesis in regulation of melanoma behavior: melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways.
Not available
S-EPMC4221528 | biostudies-literature
UnknownFoxO6 inhibits melanogenesis partly by elevating intracellular antioxidant capacity.
Not available
S-EPMC7338776 | biostudies-literature
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