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TranscriptomicsClinical relevance of SKP2 alterations in metastatic melanoma
Melanoma cell lines were genotyped to evaluate copy number differences between nodular melanoma (NM) and superficial spreading melanoma (SSM). Cell lines were also evaluated for copy number alterations in the SKP2/p27 axis. Affymetrix SNP arrays were performed according to manufacturer's instruction...
ORGANISM(S): Homo sapiens 
2010-10-21 | E-GEOD-22305 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human melanoma cell lines (63)
63 melanoma cell lines hybridized to Affymetrix Hu133_Plus 2 oligo arrays. The aim of this study was to identify potential downstream targets of key oncogenes and TSGs in melanoma (including p14ARF, p16INK4A, BRAF etc). Publications relevant to this series include:; Johansson et al. Pigment Cell Res...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7127 | biostudies-arrayexpress
TranscriptomicsMelanoma short-term cultures and cell lines: expression profiling and CNV analyses
This SuperSeries is composed of the following subset Series: GSE17349: Expression data for melanoma short-term cultures and cell lines GSE17359: Affymetrix SNP array data for 3 melanoma short-term cultures and cell lines GSE20156: RNA-Seq of melanoma short-term cultures and cell lines Refer to indiv...
ORGANISM(S): Homo sapiens 
2010-02-01 | E-GEOD-17593 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Melanoma cell lines to investigate differences in wild-type p14ARF and mutant 14ARF
35 Melanoma cell lines hybridized to Affymetrix Hu133_Plus 2 microarrays were analysed for genes differentially expressed between cell lines carrying wild-type p14ARF and those with mutant 14ARF. All of these cell lines contained wild-type p53 (so that the effects of p14ARF mutations could be analys...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7152 | biostudies-arrayexpress
GenomicsAnalysis of paired primary and metastatic cell lines identifies common DNA methylation changes in melanoma metastasis.
Using 1 melanocyte and 6 melanoma cell line (3 pair of primary and metastatic), we generated base-resolution DNA methylation maps to document DNA methylation drivers of melanoma metastasis. Here we generated single-nucleotide resoultion DNA methylation map of a total of 7 cell lines using Reduced Re...
ORGANISM(S): Homo sapiens 
2017-05-17 | E-GEOD-70621 | biostudies-arrayexpress
TranscriptomicsGene expression profilling of metastatic melanoma cell lines
Melanoma can progress rapidly from a slow-growing surgically curable lesion to aggressive metastatic disease, with high mortality and poor response to current therapies. The mechanisms underlying melanoma progression and resistance to therapeutic agents are not well understood. There are few treatme...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-16404 | biostudies-arrayexpress
TranscriptomicsExpression data from BRAF-mutant melanoma cell lines
Melanoma cell lines were assessed for differences in gene expression patterns between the lines sensitive and resistant to BRAF and MEK inhibitor drugs. 22 BRAF-mutant melanoma cell lines were assessed for response to BRAF and MEK inhibitors in a 3 day drug treatment dose response assay. Based on t...
ORGANISM(S): Homo sapiens 
2015-08-26 | E-GEOD-45558 | biostudies-arrayexpress
TranscriptomicsMicroRNA Expression Profiles Associated with Mutational Status and Survival in Malignant Melanoma
In order to improve our understanding of microRNA (miRNA) deregulation in melanoma development and possible consequences for patient survival, miRNA expression profiles were determined, using an array based approach, in melanoma tumors, melanoma cell lines and normal melanocytes. Differentially expr...
ORGANISM(S): Homo sapiens 
2010-04-21 | E-GEOD-19387 | biostudies-arrayexpress
TranscriptomicsExpression data from melanoma cell lines
Differential gene expression analysis of parental and resistant sub-lines of melanoma cell lines treated or untreated with PLX4032 Using microarray we sought to obtain a genome-wide profile of differentially expressed genes in parental melanoma cell lines and resistant sub-lines in response to PLX40...
ORGANISM(S): Homo sapiens 
2010-11-26 | E-GEOD-24862 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human melanoma cell lines treated with 5-Aza-2-deoxycytidine to identify novel tumor suppressor genes silenced by methylation in melanoma
Malignant melanoma is a common and frequently lethal disease. Current therapeutic interventions have little effect on survival, emphasizing the need for a better understanding of the genetic, epigenetic, and phenotypic changes in melanoma formation and progression. We identified genes that were not ...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9118 | biostudies-arrayexpress
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