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MetabolomicsMetabolite assay of T cells that are antigen-specially activated by viscoelastic synthetic antigen presenting cells

Adoptive T cell receptor (TCR)–based immunotherapy offers a powerful strategy to target solid tumors. However, the physical properties of the antigen-presenting interface regulate T cell metabolic programming remains poorly defined. Here we develop synthetic viscoelastic activating cells (SynVAC)...

2026-09-03 | MTBLS15444 | MetaboLights
TranscriptomicsClinical relevance of SKP2 alterations in metastatic melanoma
Melanoma cell lines were genotyped to evaluate copy number differences between nodular melanoma (NM) and superficial spreading melanoma (SSM). Cell lines were also evaluated for copy number alterations in the SKP2/p27 axis. Affymetrix SNP arrays were performed according to manufacturer's instruction...
ORGANISM(S): Homo sapiens 
2010-10-21 | E-GEOD-22305 | biostudies-arrayexpress
GenomicsLoss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
DNA methylation at the 5-position of cytosine (5-mC) is a key epigenetic mark critical for varius biological and pathological processes. 5-mC can be converted to 5-hydroxymethylcytosine (5-hmC) by the Ten-Eleven Translocation (TET) family of DNA hydroxylases. Here we report that "loss of 5-hmC&...
ORGANISM(S): Homo sapiens 
2012-09-18 | E-GEOD-38231 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of different human melanoma cells in response to 5-aza-deoxycytidine
(subset of yale_halaban_skinspore_1) expression analysis in response to 5-aza-deoxycytidine and normal melanocytes versus melanoma.
ORGANISM(S): Homo sapiens 
2010-01-18 | E-MTAB-185 | biostudies-arrayexpress
TranscriptomicsVEGFR-1 expressed by malignant melanoma initiating cells is required for tumor growth
Melanoma growth is driven by malignant melanoma initiating cells (MMIC) identified by expression of the ATP-binding cassette (ABC) member, ABCB5. ABCB5+ melanoma subpopulations have been shown to overexpress the vasculogenic differentiation markers CD144 (VE-cadherin) and TIE-1 and are associated...
ORGANISM(S): Homo sapiens 
2011-01-13 | E-GEOD-26569 | biostudies-arrayexpress
ProteomicsQuantitative proteomics of melanoma metastases derived from adherent cells or suspended cells.
Detachment of melanoma and survival under anchorage-independency were recognized as initial step of tumor metastasis. Our previous studies showed altered gene expression contributed to loss of cell invasiveness, enhanced chemosensitivity, and enhanced subcutaneous tumor formation. In this study, we ...
ORGANISM(S): Homo sapiens (Human) 
2020-08-07 | PXD011883 | Pride
Human Melanoma Anchorage independency 
TranscriptomicsExpression data from BRAFV600E A375 melanoma cells treated with vehicle or vemurafenib
Vemurafenib is a BRAF inhibitor with specificity for the most common BRAF mutant encountered in melanomas (BRAFV600E). Vemurafenib suppresses the proliferation of BRAF mutant human melanoma cells by suppressing downstream activation of the MEK/ERK mitogen activated protein kinases. We used microarra...
ORGANISM(S): Homo sapiens 
2014-05-20 | E-GEOD-42872 | biostudies-arrayexpress
TranscriptomicsGene expression in melanocytes and metastases melanoma cells from the pig
Melanoblastoma-bearing Libechov minipigs (MeLiM) provide an animal model for the study of spontaneous cutaneous melanoma. We compared the serial analysis of gene expression (SAGE) profile between normal skin melanocytes and melanoma cells from a pulmonary metastasis of MeLiM. Keywords: disease stat...
ORGANISM(S): Sus scrofa 
2008-05-07 | E-GEOD-5982 | biostudies-arrayexpress
TranscriptomicsExpression analysis of zebrafish melanoma and skin from the mitf-BRAFV600E;p53-/- line
Investigation of expression differences between skin and melanomas from a transgenic BRAFV600E zebrafish model of melanoma The embryos described in this study are further analyzed in a manuscript submitted for publication by White, et al. A 15 chip study using RNA extracted from either WT zebrafish ...
ORGANISM(S): Danio rerio 
2011-03-30 | E-GEOD-24528 | biostudies-arrayexpress
TranscriptomicsMelan-a melanocytes and B16 melanoma cells
This SuperSeries is composed of the following subset Series: GSE11580: Time course RA-treatment of B16 mouse melanoma cells GSE11584: Melan-a mouse melanocytes vs. B16 mouse melanoma cells Keywords: SuperSeries Refer to individual Series
ORGANISM(S): Mus musculus 
2008-07-31 | E-GEOD-11588 | biostudies-arrayexpress
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