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ProteomicsWhole Cell and Ubiquitinated Proteome of the Endoplasmic Reticulum (ER) Stress Response to Mild Hypothermic Culture Conditions in Chinese Hamsters Ovary Cells
This study investigates the impact of mild hypothermic conditions (31°C) on the whole cell proteome and ubiquitinated proteome of Chinese hamster ovary (CHO) cells, with a specific focus on endoplasmic reticulum (ER) proteins and ER stress. Using high-resolution mass spectrometry, we conducted a com...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2025-12-22 | PXD063085 | Pride
Label free Cell culture Cho Ubiquitin Lc-ms/ms 
ProteomicsLung Cancer Drug resistance LC-MS/MS
In depth label free quantitative mass spectrometry based proteomics for identification of potential biomarkers of drug resistance in lung cancer.
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD036996 | Pride
Drug resistance Dlkp Lung cancer Biomarker 
ProteomicsComparative label-free proteomic analysis of multiple CHO cell lines under tunicamycin-induced ER stress and proteasome inhibition
Chinese Hamster Ovary (CHO) cells are widely utilised in the biopharmaceutical industry to produce therapeutic proteins. Understanding the mechanisms of endoplasmic reticulum (ER) stress and its interplay with protein degradation pathways remains pivotal for improving production efficiency and produ...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2026-08-17 | PXD069782 | Pride
Stress Tunicamycin Cho Lc-ms/ms 
TranscriptomicsGene expression profiling of Chinese Hamster Ovary production cell lines
The dataset set consists of 295 microarrays from 121 individual CHO cultures producing a range of biologics including monoclonal antibodies, fusion proteins and therapeutic factors; non-producing cell lines were also included. Samples were taken from a wide range of process scales and formats that v...
ORGANISM(S): Cricetulus griseus 
2011-07-27 | E-GEOD-30321 | biostudies-arrayexpress
ProteomicsA comparative quantitative LC-MS/MS profiling analysis of human pancreatic adenocarcinoma, adjacent-normal tissue, and patient-derived tumour xenografts
This study describes the comparative quantitative LC-MS/MS proteomic analysis of the membrane-enriched proteome of 10 human pancreatic ductal adenocarcinomas, 9 matched adjacent-normal pancreas and patient derived xenografts (PDX) in mice (10 at F1 generation and 10 F2).
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-01-17 | PXD010841 | Pride
Pancreatic cancer Mass spectrometry Lc-ms/ms 
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