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ProteomicsMemantine administration enhances glutamatergic and GABAergic pathways in human hippocampus of Alzeimer´s disease patients
Alzheimer´s disease (AD) represents a serious health, social and economic problem. One of the traditional treatment is administration of memantine, the NMDA receptor antagonist. In this study we investigated how memantine medication impacts protein expression in hippocampus of AD patients using TMT-...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD052958 | Pride
Memantine  ffpe  alzheimer´s disease  proteomics  hippocampus  glutamate receptors  metabolism 
ProteomicsProteomic profiling of hippocampus and cerebral cortex in triple-transgenic mouse model of Alzheimer’s disease: Alterations with memantine treatment, part 2
INTRODUCTION Alzheimer’s disease (AD) is an advanced neurodegenerative disorder characterized by progressive impairment in both memory loss and cognitive capacities, which resulting in severe dementia [1]. The pathogenesis of AD is complicated and poorly understood. According to the World Alzheimer ...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD012110 | Pride
Memantine (mem) Alzheimer’s disease (ad) Proteomics 
GenomicsTranscriptome analysis of memantine-treated Shank2 wild-type and knock-out mice
Transcriptome analysis of memantine-treated Shank2 wild-type and knock-out mice
PRJNA721409 | ENA
TranscriptomicsMolecular profile of ketamine in comparison to memantine and phencyclidyne and other psychotropic drugs [mouse hippocampus]
Ketamine has been found to elicit a rapid antidepressant effects in treatment-refractory affective disorders. To indicate the underlying mechanism of action we have performed whole-genome microarray profiling. Moreover, the effects of ketamine were compared to other NMDA receptor antagonists phencyc...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-73798 | biostudies-arrayexpress
TranscriptomicsMolecular profile of ketamine in comparison to memantine and phencyclidyne and other psychotropic drugs [mouse striatum]
Ketamine has been found to elicit a rapid antidepressant effects in treatment-refractory affective disorders. To indicate the underlying mechanism of action we have performed whole-genome microarray profiling. Moreover, the effects of ketamine were compared to other NMDA receptor antagonists phencyc...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-73799 | biostudies-arrayexpress
ClinicalMemantine Hydrochloride in Helping Cancer Survivors Stop Smoking
RATIONALE: Memantine hydrochloride may help people stop smoking by decreasing the symptoms of nicotine withdrawal. PURPOSE: This randomized, pilot phase II trial studies how effective memantine hydrochloride works compared to placebo in helping cancer survivors stop smoking.
2120504 | ecrin-mdr-crc
TranscriptomicsTranscriptome analysis of memantine-treated Shank2 wild-type and knock-out mice
Shank2 is an excitatory postsynaptic scaffolding protein strongly implicated in autism spectrum disorders (ASD). Shank2-mutant mice with a homozygous deletion of exons 6 and 7 show decreased NMDA receptor (NMDAR) functions and autistic-like behaviors in juvenile (~postnatal day or P21) and adult (> ...
ORGANISM(S): Mus musculus 
2021-10-06 | GSE171931 | GEO
GenomicsHigh-frequency head impacts cause chronic synaptic adaptations and long-term cognitive impairment [Memantine study]
High-frequency head impacts cause chronic synaptic adaptations and long-term cognitive impairment [Memantine study]
PRJNA695800 | ENA
TranscriptomicsMolecular profile of ketamine in comparison to memantine and phencyclidyne and other psychotropic drugs [mouse striatum]
Ketamine has been found to elicit a rapid antidepressant effects in treatment-refractory affective disorders. To indicate the underlying mechanism of action we have performed whole-genome microarray profiling. Moreover, the effects of ketamine were compared to other NMDA receptor antagonists phencyc...
ORGANISM(S): Mus musculus 
2015-12-31 | GSE73799 | GEO
TranscriptomicsMolecular profile of ketamine in comparison to memantine and phencyclidyne and other psychotropic drugs [mouse hippocampus]
Ketamine has been found to elicit a rapid antidepressant effects in treatment-refractory affective disorders. To indicate the underlying mechanism of action we have performed whole-genome microarray profiling. Moreover, the effects of ketamine were compared to other NMDA receptor antagonists phencyc...
ORGANISM(S): Mus musculus 
2015-12-31 | GSE73798 | GEO
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