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MetabolomicsNPC1 regulates the distribution of phosphatidylinositol 4 kinases at Golgi and Lysosome membranes
Cholesterol and phosphoinositides (PI) are two critically important lipids that are found in cellular membranes and dysregulated in many disorders. Therefore, uncovering molecular pathways connecting these essential lipids may offer new therapeutic insights. We report that loss of function of lysoso...
2021-09-15 | MTBLS2612 | MetaboLights
ProteomicsHuman VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs
Membrane contact sites (MCS) are intracellular regions where two organelles come closer to exchange information and material. The majority of the endoplasmic reticulum (ER) MCS are attributed to the ER-localized tether proteins VAPA, VAPB, and MOSPD2. These recruit other proteins to the ER by intera...
ORGANISM(S): Homo sapiens (Human) 
2023-06-29 | PXD043399 | Pride
Emery-dreifuss muscular dystrophy  ffat  ffnt  mospd1  mospd2  mospd3  vapa  vapb  endoplasmic reticulum  membrane contact sites 
ProteomicsPDZD8 interacts with Protrudin and Rab7 to form an ER-late endosome membrane contact site that recruits mitochondria
Endosomes regulate a plethora of cellular processes including signaling, nutrient status and organelle quality control by controlling the fate of material entering the cells. Endosomes undergo a process of maturation which specifies whether material will be shuttled back to the cell surface or degra...
ORGANISM(S): Homo sapiens (Human) 
2020-06-02 | PXD015523 | Pride
Human Ls-ms/ms Q exactive plus 
ProteomicsPex30-dependent membrane contacts sites maintain ER lipid homeostasis
In eukaryotic cells, communication between organelles and the coordination of their activities depend on membrane contact sites (MCS). How MCS are regulated under the dynamic cellular environment remains poorly understood. Here, we investigate how Pex30, a membrane protein localized to the endoplasm...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-05-08 | PXD056055 | Pride
Endoplasmic reticulum  lipid droplet  peroxisome  pex30  nvj  membrane contact site  dysferlin  duf4196  phosphatidic acid 
ProteomicsSpatiotemporal profiling of membrane proteins involved in organelle communication
Organelle communication is largely mediated by proteins at membrane contact sites (MCS), such as the endoplasmic reticulum (ER)-mitochondria, ER-plasma membrane (PM), and mitochondria-lipid droplets (LD). In this project, we developed a new tool for identifying membrane proteins at MCS by utilizing ...
ORGANISM(S): Homo Sapiens (human) Cellular Organisms 
2024-01-27 | PXD040926 | JPOST Repository
ProteomicsThe Legionella-driven PtdIns(4)P gradient at LCV-ER membrane contact sites promotes Vap-, OSBP and Sac1-dependent pathogen vacuole remodeling
The causative agent of Legionnaires’ disease, Legionella pneumophila, governs interactions with host cells by secreting ca. 330 different “effector” proteins. The facultative intracellular bacteria replicate in macrophages and amoeba within a unique compartment, the Legionella-containing vacuole (LC...
ORGANISM(S): Legionella pneumophila subsp. pneumophila str. Philadelphia 1 Dictyostelium discoideum 
2023-02-21 | PXD034490 | Pride
Large fusion gtpase Oxysterol binding protein Legionella pneumophila Atlastin Legionnaires’ disease Host-pathogen interaction Pathogen vacuole Amoeba Dictyostelium discoideum 
UnknownPex30-dependent membrane contact sites maintain ER lipid homeostasis.
Not available
S-EPMC12101078 | biostudies-literature
GenomicsVAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites
VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites
PRJNA777941 | ENA
ProteomicsIdentification of a lipid droplet-plasma membrane tethering complex
Membrane contact sites (MCS) are interorganellar contacts that allow for the direct exchange of molecules such as lipids or Ca2+ between organelles, but can also be a mean for tethering of organelles. In mammals and yeast, LDs have been shown to engage in MCS with nearly all organelles in the cell, ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-06-09 | PXD022769 | Pride
Seedling Membrane contact sites Arabidopsis Tag Tethering complex Seed Lipid droplets Germination Plasma membrane 
UnknownMembrane contact sites regulate vacuolar fission via sphingolipid metabolism.
Not available
S-EPMC10972560 | biostudies-literature
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