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MetabolomicsER fusogens maintain membrane reservoir to ensure brain function
How the morphological dynamics of the endoplasmic reticulum (ER) are linked to its functions is unclear. Atlastins (ATLs), a class of GTPases, mediate ER fusion, and human mutations in ATL1 cause hereditary spastic paraplegia (HSP). Here, we show that ATL2-knockout mice are embryonic lethal with com...
2026-07-08 | MTBLS14970 | MetaboLights
MetabolomicsLION-web validation lipidomics experiments (FA-incorporation, membrane fluidty)
A major challenge for lipidomic analyses is the handling of the large amounts of data and the translation of results to interpret the involvement of lipids in biological systems. We built a new lipid ontology (LION) that associates over 50,000 lipid species to biophysical, chemical and cell biologic...
2019-04-24 | MTBLS757 | MetaboLights
MetabolomicsModification of erythrocyte membrane phospholipid composition in preterm newborns with retinopathy of prematurity: The omegaROP study

N-3 polyunsaturated fatty acids (PUFAs) may prevent retinal vascular abnormalities observed in oxygen-induced retinopathy, a model of retinopathy of prematurity (ROP). In the OmegaROP prospective cohort study, we showed that preterm infants who will develop ROP accumulate the n-6 PUFA arachidonic...

2022-09-07 | MTBLS4219 | MetaboLights
TranscriptomicsERK5 Regulates Muscle Cell Fusion through Klf Transcription Factors
In skeletal muscle differentiation, muscle-specific genes are regulated by two groups of transcription factors, the MyoD and MEF2 families, which work together to drive the differentiation process. Here we show that ERK5 regulates muscle cell fusion through Klf transcription factors. The inhibition ...
ORGANISM(S): Mus musculus 
2011-02-21 | E-GEOD-25827 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq reveals activation of unique gene groups as a consequence of stem cell-parenchymal cell fusion
Fusion of donor mesenchymal stem cells with parenchymal cells of the recipient can occur in the brain, liver, intestine and heart following transplantation. The therapeutic benefit or detriment of resultant hybrids is unknown. Here we sought a global view of phenotypic diversification of mesenchym...
ORGANISM(S): Mus musculus 
2016-03-22 | E-GEOD-69926 | biostudies-arrayexpress
TranscriptomicsCell Fusion Enhances Mesendodermal Differentiation of Human Induced Pluripotent Stem Cells.
Human induced pluripotent stem cells (iPS cells) resemble embryonic stem cells and can differentiate into cell derivatives of all three germ layers. However, frequently the differentiation efficiency of iPS cells into some lineages is rather poor. Here, we found that fusion of iPS cells with human h...
ORGANISM(S): Homo sapiens 
2014-08-06 | E-GEOD-58457 | biostudies-arrayexpress
ProteomicsMetal organic layers enabled cell surface engineering coupling biomembrane fusion for dynamic membrane proteome profiling
Systematically dissecting the highly dynamic and tightly communicating membrane proteome of living cells is essential for systems-level understanding of fundamental cellular processes and intricate relationship between membrane-bound organelles constructed through membrane traffic. While extensive e...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD044945 | Pride
Membrane protein enrichment metal organic layers proteome 
ProteomicsCoro1a promotes the multivesicular body and plasma membrane fusion by facilitating PKM2-mediated SNAP-23 phosphorylation
During the formation of endosomal pathway-dependent extracellular vesicles (EVs), intraluminal vesicles in multivesicular bodies (MVBs) fuse with the plasma membrane (PM), releasing intraluminal vesicles to produce exosomes. Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNAR...
ORGANISM(S): Homo Sapiens 
2025-12-07 | PXD071700 |
TranscriptomicsPandemic H1N1 Influenza A Directly Induces a Robust and Acute Inflammatory Gene Signature in Primary Human Bronchial Epithelial Cells Downstream of Membrane Fusion
Pandemic H1N1 influenza A (H1N1pdm) elicits stronger pulmonary inflammation than previously circulating seasonal H1N1 influenza A (sH1N1), yet mechanisms of inflammatory activation in respiratory epithelial cells during H1N1pdm infection are unclear. We investigated host responses to H1N1pdm / sH1N...
ORGANISM(S): Homo sapiens 
2016-07-04 | E-GEOD-48575 | biostudies-arrayexpress
ProteomicsA plant-specific mitochondria outer membrane protein regulates mitochondrial fusion
Mitochondria are essential organelles in eukaryotes for energy production and are composed by a double-layered membrane structure that contains a smooth mitochondrial outer membrane (MOM) and a highly invaginated mitochondrial inner membrane (MIM). Mitochondria are dynamic with the ability to fuse a...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-09-05 | PXD039252 | Pride
Mitochondria Aggregating vacuole Outer membrane 
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