Membrane mimetic thermal proteome profiling

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2025 (2)

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Department of Biochemistry and Molecular Biology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada. (1)
University of British Columbia, Faculty of Medicine, Department of Biochemistry and Molecular Biology, Life Sciences Institute (1)

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Membrane mimetic thermal proteome profiling (MM-TPP) towards mapping membrane protein-ligand dynamic interactions

Integral membrane proteins (IMPs) are key targets for small-molecule therapeutics. However, robust, unbiased, and detergent-free methods to probe on- and off-target interactions within this protein class remain underdeveloped. Previously, we introduced the Peptidisc membrane mimetic (MM) for water-s...

ORGANISM(S): Mus musculus (Mouse)

2025-11-17 | PXD068828 | Pride

Membrane mimetic thermal proteome profiling (MM-TPP) towards mapping membrane protein-ligand dynamics

We combine the membrane mimetic (MM) Peptidisc with thermal proteome profiling (TPP) to screen membrane proteomes in detergent-free environments. Using whole mouse liver, we demonstrate the stabilization of integral membrane proteins (IMPs), specifically ATP-binding cassette transporters, through in...

ORGANISM(S): Mus musculus (Mouse) Escherichia coli

2025-11-17 | PXD055093 | Pride

Membrane mimetic Mouse liver Thermal proteome profiling

Membrane-mimetic thermal proteome profiling (MM-TPP) toward mapping membrane protein-ligand dynamic interactions.

Not available

S-EPMC12611261 | biostudies-literature

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