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TranscriptomicsA procedure to identify peptides with -AMP activity
We showed previously that insertion of Synechocystis 12-desaturase in Salmonellas membrane alters membrane physical state (MPS) followed by the expression of stress genes causing inability to survive within murine macrophages . Recently, we showed that expression of one membrane lipid domain (MLD) o...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 
2016-07-15 | E-MTAB-4544 | biostudies-arrayexpress
TranscriptomicsRNA sequencing–based determination of the RNA interactome of wild-type AKAP1 and its deletion mutants deficient for the KH or Tudor domain.
AKAP1 is highly expressed in glioblastoma and is required for tumor growth. We therefore analyzed the AKAP1 RNA interactome in glioblastoma cells. Native RNA immunoprecipitation followed by high-throughput sequencing (RIP-Seq) was performed in U87MG cells transiently expressing V5-tagged mouse wild-...
ORGANISM(S): Homo sapiens 
2026-09-01 | E-MTAB-16473 | biostudies-arrayexpress
TranscriptomicsRNASeq - Epigenetic Activation of AKT1 Drives Metabolic Reprogramming in Advanced-Stage Lipedema: A Multi-Omics Study
Lipedema is a chronic, progressive adipose disorder affecting predominantly women, characterized by painful, symmetrical accumulation of subcutaneous fat in the limbs, and typically resistant to diet or exercise. The underlying pathophysiology of advanced stages remains poorly defined, and no valida...
ORGANISM(S): Homo sapiens 
2025-08-12 | E-MTAB-15370 | biostudies-arrayexpress
TranscriptomicsMethylationEPIC - Epigenetic Activation of AKT1 Drives Metabolic Reprogramming in Advanced-Stage Lipedema: A Multi-Omics Study
Lipedema is a chronic, progressive adipose disorder affecting predominantly women, characterized by painful, symmetrical accumulation of subcutaneous fat in the limbs, and typically resistant to diet or exercise. The underlying pathophysiology of advanced stages remains poorly defined, and no valida...
ORGANISM(S): Homo sapiens 
2025-08-12 | E-MTAB-15365 | biostudies-arrayexpress
TranscriptomicsCharacterization of the roles of the RNA-binding protein AUF-1 in airway epithelial inflammatory responses
The RNA-binding protein AU-rich-element factor-1 (AUF-1) regulates mRNA decay and translation of genes during inflammation and cellular senescence, two pathogenic mechanisms of chronic obstructive pulmonary disease (COPD). Decreased AUF-1 expression was described in bronchiolar epithelium of COPD pa...
ORGANISM(S): Homo sapiens 
2023-04-14 | E-MTAB-12583 | biostudies-arrayexpress
TranscriptomicsUncoupling effects of ERalfa on LKB1/AMPK interaction upon adiponectin exposure in breast cancer
Adipose tissue is a metabolic and endocrine organ that secretes numerous bioactive molecules called adipocytokines. Among these, adiponectin has been argued to have a crucial role in obesity-associated breast cancer. The key molecule of adiponectin signaling is AMP-activated protein kinase (AMPK), m...
ORGANISM(S): Homo sapiens 
2020-02-27 | E-MTAB-6120 | biostudies-arrayexpress
TranscriptomicsRNA-Seq in Vivo 272 Non-coding RNA profiling in BRAFV600E-mutant cutaneous melanoma models before and after Spry1 depletion
Mitogen-activated protein kinase (MAPK) pathway activation is a central step in BRAFV600E-mutant cutaneous melanoma (CM) pathogenesis. In the last years, Spry1 has been frequently described as an upstream regulator of MAPK signaling pathway. However, its specific role in BRAFV600E-mutant CM is still...
ORGANISM(S): Homo sapiens 
2025-08-12 | E-MTAB-15369 | biostudies-arrayexpress
TranscriptomicsRNA-Seq Non-coding RNA profiling in BRAFV600E-mutant cutaneous melanoma models before and after Spry1 depletion
Mitogen-activated protein kinase (MAPK) pathway activation is a central step in BRAFV600E-mutant cutaneous melanoma (CM) pathogenesis. In the last years, Spry1 has been frequently described as an upstream regulator of MAPK signaling pathway. However, its specific role in BRAFV600E-mutant CM is still...
ORGANISM(S): Homo sapiens 
2025-06-10 | E-MTAB-15186 | biostudies-arrayexpress
TranscriptomicsCombinatorial Inhibition of Menin and the Histone Methyltransferase DOT1L as a Novel Therapeutic Strategy for Ovarian Cancer Treatment
Descrizione ProvvisoriaPurpose OC is characterized by a low response rate and high frequency of resistance development to currently available treatments, indicating to an urgent need for the identification of novel and more effective therapies. Several studies demonstrated DOT1L therapeutic potentia...
ORGANISM(S): Homo sapiens 
2026-08-01 | E-MTAB-11800 | biostudies-arrayexpress
TranscriptomicsEstrogen receptor beta inhibits cholesterol biosynthesis through overexpression of mir-181a-5p in Triple Negative Breast Cancer
Triple negative breast cancer (TNBC) is a highly heterogeneous disease representing the most aggressive breast cancer (BC) subtype. Lack of Estrogen Receptor alpha (ERα), progesterone receptor (PR) and epidermal growth factor receptor 2 (HER2/neu) expression makes TNBC immune to common therapies, si...
ORGANISM(S): Homo sapiens 
2020-04-04 | E-MTAB-8807 | biostudies-arrayexpress
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