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MetabolomicsPlasma Lipidomics Identifies Anticedent Memory Impairment in Older Adults
Alzheimer's disease causes a progressive dementia that currently affects over 35 million individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no cures or disease-modifying therapies, and this may be due to our inability to detect the disease before it has progresse...
2014-03-09 | MTBLS72 | MetaboLights
TranscriptomicsTranscription profiling of hippocampi from scopolamine treated adult rats following stimulation in a spatial memory task
Hippocampal gene expression profiling in scopolamine treated adult rats following stimulation in a spatial memory task
ORGANISM(S): Rattus norvegicus 
2006-12-30 | E-MEXP-920 | biostudies-arrayexpress
ProteomicsDiscovery of a Small Molecule Secreted Clustering Enhancer that Improves Memory in Alzheimer's Disease Mice
Here, we present findings from a drug discovery program aimed at developing small molecules that enhance brain sCLU levels and assessed their impact on AD pathology and cognition. A high-throughput screening campaign identified two classes of epigenetic modulators to increase sCLU levels, and medici...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-30 | PXD060171 | Pride
Alzheimers disease Epigenetic modulator Memory improvement Secreted clustering enhancer 
TranscriptomicsHippocampal expression data from FTY720- and vehicle-treated SCID mice following fear consolidation testing
FTY720/Fingolimod, an FDA-approved drug for treatment of multiple sclerosis, has beneficial effects in the CNS that are not yet well understood, independent of its effects on immune cell trafficking. Here we show that FTY720 enters the nucleus where it is phosphorylated by sphingosine kinase 2 (SphK...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-57015 | biostudies-arrayexpress
UnknownSpermidine-induced improvement of reconsolidation of memory involves calcium-dependent protein kinase in rats.
Not available
S-EPMC4749837 | biostudies-literature
UnknownCan short-term memory be trained?
Not available
S-EPMC6647533 | biostudies-literature
UnknownNeural predictors of cognitive improvement by multi-strategic memory training based on metamemory in older adults with subjective memory complaints.
Not available
S-EPMC5773558 | biostudies-literature
UnknownPeripheral NMDAR subunits as predictors of working memory improvement in schizophrenia.
Not available
S-EPMC12612181 | biostudies-literature
ProteomicsScanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction
A prevalent view in treating age-dependent disorders including Alzheimer’s disease (AD) is that the underlying amyloid plaque pathology must be targeted for cognitive improvements. In contrast, we report here that repeated scanning ultrasound (SUS) treatment at 1 MHz frequency can ameliorate memory ...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-19 | PXD050248 | Pride
Blood-brain barrer Amyloid-β Quantitative proteomics Alzheimer's disease 
UnknownUnderstanding the roles of central and autonomic activity during sleep in the improvement of working memory and episodic memory.
Not available
S-EPMC9636982 | biostudies-literature
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