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TranscriptomicsHCT116 cells isogenic for p53 expression upon treatment with actinomycin D and nutlin-3
HCT116 wild type cells express p53. The isogenic HCT116 p53KO cells have the p53 gene knocked out. Cells were treated for 16 hours. Dosages for actinomycin D treatment was 1 nM, 10 nM, and 100 nM. Dosage for nutlin-3 was 4 uM. Keywords: dose response Measuring the gene expression profile of the is...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-12459 | biostudies-arrayexpress
ProteomicsCharacterization of progressive denaturation and unfolding intermediates of proteins by fast cross-linking using di-ortho-phthalaldehyde
Chemical cross-linking of proteins coupled with mass spectrometry (CXMS) is widely used in protein structural analysis. In this study we develop a new class of non-hydrolyzable amine-selective di-ortho-phthalaldehyde (DOPA) cross-linkers, one of which is DOPA2. Cross-linking of proteins with DOPA2 i...
ORGANISM(S): Staphylococcus Aureus Bos Taurus 
2021-12-20 | PXD030552 |
TranscriptomicsRNAi knockdown of NMD in D Melanogaster
Two core factors of the NMD machinery in D. melanogaster, Upf1 and Upf2, were knocked down using RNAi, as described in Rehwinkel et al. (2005) RNA, PMID: 16199763. Each of the two knockdowns were compared to mock RNAi knockdowns as described in Blanchette et al. (2005) Genes Dev, PMID: 15937219 in a...
ORGANISM(S): Drosophila melanogaster 
2010-05-18 | E-GEOD-13532 | biostudies-arrayexpress
Unknown3,4-O-(2,3-Dimethoxy-butane-2,3-di-yl)-S-(4-methyl-phen-yl)-1-thia-α-d-manno-pyran-oside.
Not available
S-EPMC2961734 | biostudies-literature
UnknownA molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration.
Not available
S-EPMC10166177 | biostudies-literature
TranscriptomicsmicroRNA Expression in HCC Tissues and Cells
Cell Lines, Cultures and HCC Tumor Tissues.
Malignant and non-malignant hepatocyte cell lines were obtained from the American Type Culture Collection (Manassas, VA) and cultured as recommended by the supplier. Total RNA from three paires of normal human liver tissue and from hepatocellular car...
ORGANISM(S): Homo sapiens 
2011-08-03 | E-MEXP-1125 | biostudies-arrayexpress
UnknownVoltage-Dependent Emission Varying from Blue to Orange-Red from a Nondoped Organic Light-Emitting Diode with a Single Emitter.
Not available
S-EPMC9320025 | biostudies-literature
TranscriptomicsUbe3a-ATS characterization with strand-speicific microarray
This strand-specific array is performed to characterize expression features of Ube3a-ATS, including its imprinting status, its exon-intron structure, its transcriptional initiation and termination site as well as its polyadenylation status. The array contains reverse-complementary probes detecting t...
ORGANISM(S): Mus musculus 
2012-05-02 | E-GEOD-29254 | biostudies-arrayexpress
UnknownAberrant allelic-switch of antisense lncRNA IRAIN may be an early diagnostic marker in laryngeal cancer.
Not available
S-EPMC7436268 | biostudies-literature
TranscriptomicsConvergent Sense/Antisense Transcription At Intragenic Super-Enhancers Targets AID-initiated Genomic Instability
Activation-induced cytidine deaminase (AID) initiates both somatic hypermutation (SHM) for antibody affinity maturation and DNA breakage for antibody class switch recombination (CSR) via transcription-dependent cytidine deamination of single stranded DNA targets. While largely specific for immunglob...
ORGANISM(S): Homo sapiens 
2014-12-04 | E-GEOD-62296 | biostudies-arrayexpress
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