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ProteomicsSuccinylation modification provides a new sight in the treatment of immunocompromised populations with drug-resistant Aspergillus fumigatus infection
The invasive infection of Aspergillus fumigatus poses a serious threat to human health worldwide, especially in immunocompromised patients. At present, triazole drugs are the most common antifungal drugs for aspergillosis. However, due to the emergence of drug-resistant strains, the effect of triazo...
ORGANISM(S): Aspergillus Fumigatus 
2023-02-15 | PXD040137 |
ProteomicsDiscovery of a cooperative mode of inhibiting RIPK1 kinase
By using Limited Proteolysis-Mass Spectrometry (LiP-MS) and Hydrogen Deuterium Exchange-Mass Spectrometry (HDX-MS) analysis, we identified the binding pocket of Nec-34 in RIPK1 kinase domain. This newly identified binding pocket of Nec-34 is distinct from distinct from that of Nec-1s.
ORGANISM(S): Homo Sapiens 
2021-03-07 | PXD024560 |
ProteomicsDiscovery of a cooperative mode of inhibiting RIPK1
We identified a peptide of RIPK1 binding with compound Nec-34
ORGANISM(S): Homo Sapiens 
2021-03-04 | PXD024534 |
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